滤纸过滤咖啡会增加胆固醇和炎症生物标志物，与烘焙程度无关：一项临床试验。

Paper-filtered coffee increases cholesterol and inflammation biomarkers independent of roasting degree: a clinical trial.

机构信息

Department of Nutrition, School of Public Health, University of São Paulo, São Paulo, Brazil.

出版信息

Nutrition. 2013 Jul-Aug;29(7-8):977-81. doi: 10.1016/j.nut.2013.01.003. Epub 2013 Mar 17.

DOI:10.1016/j.nut.2013.01.003

PMID:23510568

Abstract

OBJECTIVE

The aim of this study was to compare the effects of medium light roast (MLR) and medium roast (MR) paper-filtered coffee on cardiovascular risk factors in healthy volunteers.

METHODS

This randomized crossover trial compared the effects of consuming three or four cups (150 mL) of MLR or MR coffee per day for 4 wk in 20 healthy volunteers. Plasma lipids, lipoprotein(a) (Lp[a]), total homocysteine, and endothelial dysfunction-related inflammation biomarkers, serum glycemic biomarkers, and blood pressure were measured at baseline and after each intervention.

RESULTS

Both roasts increased plasma total cholesterol, low-density lipoprotein-cholesterol, and soluble vascular cell adhesion molecule-1 (sVCAM-1) concentrations (10%, 12%, and 18% for MLR; 12%, 14%, and 14% for MR, respectively) (P < 0.05). MR also increased high-density lipoportein-cholesterol concentration by 7% (P = 0.003). Plasma fibrinogen concentration increased 8% after MR intake (P = 0.01), and soluble E-selectin increased 12% after MLR intake (P = 0.02). No changes were observed for Lp(a), total homocysteine, glycemic biomarkers, and blood pressure.

CONCLUSION

Moderate paper-filtered coffee consumption may have an undesirable effect on plasma cholesterol and inflammation biomarkers in healthy individuals regardless of its antioxidant content.

摘要

目的

本研究旨在比较中浅度烘焙（MLR）和中度烘焙（MR）过滤咖啡对健康志愿者心血管风险因素的影响。

方法

这项随机交叉试验比较了 20 名健康志愿者每天饮用三杯或四杯（150 毫升）MLR 或 MR 咖啡，持续 4 周的效果。在基线和每次干预后，测量血浆脂质、脂蛋白（a）（Lp[a]）、总同型半胱氨酸和内皮功能障碍相关炎症生物标志物、血清血糖生物标志物和血压。

结果

两种烘焙方式均增加了血浆总胆固醇、低密度脂蛋白胆固醇和可溶性血管细胞黏附分子-1（sVCAM-1）浓度（MLR 分别增加 10%、12%和 18%；MR 分别增加 12%、14%和 14%）（P<0.05）。MR 还使高密度脂蛋白胆固醇浓度增加了 7%（P=0.003）。MR 摄入后血浆纤维蛋白原浓度增加 8%（P=0.01），MLR 摄入后可溶性 E-选择素增加 12%（P=0.02）。Lp[a]、总同型半胱氨酸、血糖生物标志物和血压没有变化。