Gonçalinho Gustavo Henrique Ferreira, Nascimento José Rafael de Oliveira, Mioto Bruno Mahler, Amato Reynaldo Vicente, Moretti Miguel Antonio, Strunz Célia Maria Cassaro, César Luiz Antonio Machado, Mansur Antonio de Padua
Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 01246-903, SP, Brazil.
Servico de Prevencao e Reabilitacao Cardiovascular, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 05403-900, SP, Brazil.
J Clin Med. 2022 May 25;11(11):2985. doi: 10.3390/jcm11112985.
Background: Coffee is one of the most popular beverages globally and contains several bioactive compounds that are relevant to human health. Many nutritional strategies modulate sirtuin-1, thereby impacting aging and cardiometabolic health. This study investigated the influence of different blended coffees on serum sirtuin-1, blood lipids, and plasma homocysteine. Methods: An eight-week randomized clinical trial that included 53 healthy adults of both sexes analyzed the effects of daily intake of 450 to 600 mL of pure Arabica or blended (Arabica + Robusta) coffee intake of filtered coffee on blood sirtuin-1, lipids, and homocysteine. Results: Both Arabica and blended coffees similarly increased serum sirtuin-1 concentration, from 0.51 to 0.58 ng/mL (p = 0.004) and from 0.40 to 0.49 ng/mL (p = 0.003), respectively, without changing plasma homocysteine, folic acid, glucose, and CRP. However, the blended coffee intake increased total cholesterol from 4.70 to 5.17 mmol/L (p < 0.001) and LDL-cholesterol from 2.98 to 3.32 mmol/L (p < 0.001), as well as HDL-c from 1.26 to 1.36 mmol/L (p < 0.001). Conclusion: Both coffee powders increased sirtuin-1 expression, but our results suggest that blended coffee had hypercholesterolemic effects which could increase cardiovascular risk. Therefore, preference should be given to Arabica coffee for the best cardiometabolic benefits of coffee.
咖啡是全球最受欢迎的饮品之一，含有多种与人类健康相关的生物活性化合物。许多营养策略可调节沉默调节蛋白-1，从而影响衰老和心脏代谢健康。本研究调查了不同混合咖啡对血清沉默调节蛋白-1、血脂和血浆同型半胱氨酸的影响。方法：一项为期八周的随机临床试验，纳入了53名健康的成年男女，分析了每日摄入450至600毫升纯阿拉比卡咖啡或混合（阿拉比卡+罗布斯塔）过滤咖啡对血液中沉默调节蛋白-1、血脂和同型半胱氨酸的影响。结果：阿拉比卡咖啡和混合咖啡均能同样程度地提高血清沉默调节蛋白-1浓度，分别从0.51纳克/毫升提高到0.58纳克/毫升（p = 0.004）和从0.40纳克/毫升提高到0.49纳克/毫升（p = 0.003），且不会改变血浆同型半胱氨酸、叶酸、葡萄糖和CRP水平。然而，饮用混合咖啡会使总胆固醇从4.70毫摩尔/升升高到5.17毫摩尔/升（p < 0.001），低密度脂蛋白胆固醇从2.98毫摩尔/升升高到3.32毫摩尔/升（p < 0.001），同时高密度脂蛋白胆固醇从1.26毫摩尔/升升高到1.36毫摩尔/升（p < 0.001）。结论：两种咖啡粉均能增加沉默调节蛋白-1的表达，但我们的结果表明混合咖啡具有高胆固醇血症效应，可能会增加心血管疾病风险。因此，为获得咖啡对心脏代谢的最佳益处，应优先选择阿拉比卡咖啡。
