Institute for Rare and Neglected Diseases Drug Discovery, Mountain View, California, USA.
Clin Pharmacol Ther. 2013 Apr;93(4):299-301. doi: 10.1038/clpt.2012.236.
Current drug discovery strategies include both molecular and empirical approaches. The molecular approaches are predominantly hypothesis-driven and are referred to as target-based. The empirical approaches are referred to as phenotypic because they rely on phenotypic measures of response. A recent analysis revealed the phenotypic approaches to be the more successful strategy for small-molecule, first-in-class medicines. The rationalization for this success was the unbiased identification of the molecular mechanism of action (MMOA).
当前的药物发现策略包括分子和经验方法。分子方法主要是假设驱动的，被称为基于靶点的。经验方法被称为表型的，因为它们依赖于反应的表型测量。最近的一项分析表明，对于小分子的首创药物来说，表型方法是更成功的策略。这种成功的合理化是对作用机制（MMOA）的无偏见识别。
