Fan Ming-Wei, Tian Jin-Lan, Chen Tan, Zhang Can, Liu Xin-Ru, Zhao Zi-Jian, Zhang Shu-Hui, Chen Yan
Department of Gastroenterology, Binzhou Medical University Hospital, Binzhou 256600, Shandong Province, China.
World J Diabetes. 2024 Oct 15;15(10):2041-2057. doi: 10.4239/wjd.v15.i10.2041.
Diabetes mellitus (DM) is one of the major causes of mortality worldwide, with inflammation being an important factor in its onset and development. This review summarizes the specific mechanisms of the cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-stimulator of interferon genes (STING) pathway in mediating inflammatory responses. Furthermore, it comprehensively presents related research progress and the subsequent involvement of this pathway in the pathogenesis of early-stage DM, diabetic gastroenteropathy, diabetic cardiomyopathy, non-alcoholic fatty liver disease, and other complications. Additionally, the role of cGAS-STING in autonomic dysfunction and intestinal dysregulation, which can lead to digestive complications, has been discussed. Altogether, this study provides a comprehensive analysis of the research advances regarding the cGAS-STING pathway-targeted therapeutic agents and the prospects for their application in the precision treatment of DM.
糖尿病（DM）是全球主要死因之一，炎症是其发病和发展的重要因素。本综述总结了环磷酸鸟苷-磷酸腺苷合成酶（cGAS）-干扰素基因刺激因子（STING）通路介导炎症反应的具体机制。此外，还全面介绍了该通路在早期糖尿病、糖尿病胃肠病、糖尿病心肌病、非酒精性脂肪性肝病及其他并发症发病机制中的相关研究进展及后续参与情况。此外，还讨论了cGAS-STING在可导致消化并发症的自主神经功能障碍和肠道失调中的作用。总之，本研究对cGAS-STING通路靶向治疗药物的研究进展及其在糖尿病精准治疗中的应用前景进行了全面分析。
