Diabetes and Endocrine Centre, Mater Dei Hospital, Msida, MSD 2090, Malta.
Acta Diabetol. 2013 Dec;50(6):859-65. doi: 10.1007/s00592-013-0464-z. Epub 2013 Mar 20.
To investigate the association between country incidence of type 1 diabetes and mortality from infectious disease and antibiotic susceptibility. An ecological study to explore the relationship at a country level of the reported incidence of type 1 diabetes (DiaMond) to infectious disease mortality (World Health Organisation) and to antibiotic susceptibility (Alexander Project). There were significant negative correlations between the incidence of type 1 diabetes and mortality for all infectious diseases studied. There were also significant positive correlations between the incidence of type 1 diabetes and antibiotic susceptibilities of Strep. pneumoniae, but not to those of Haem. influenzae. Since infectious disease mortality and antibiotic susceptibility are surrogate markers for bacterial exposure, our results provide support for a negative association between bacterial exposure in a community and its incidence of type 1 diabetes. The consistency of our results as well as the highly statistically significant results of most of the associations studied reinforces the validity of our findings.
为了研究 1 型糖尿病的国家发病率与传染病和抗生素耐药性死亡率之间的关系。采用生态研究方法，在国家层面上探讨了报道的 1 型糖尿病（DiaMond）发病率与传染病死亡率（世界卫生组织）以及抗生素耐药性（Alexander 项目）之间的关系。研究发现，1 型糖尿病的发病率与所有研究传染病的死亡率之间存在显著的负相关关系。1 型糖尿病的发病率与肺炎链球菌的抗生素耐药性之间也存在显著的正相关关系，但与流感嗜血杆菌的抗生素耐药性无关。由于传染病死亡率和抗生素耐药性是细菌暴露的替代标志物，我们的研究结果为社区细菌暴露与其 1 型糖尿病发病率之间的负相关关系提供了支持。我们的研究结果的一致性以及大多数研究关联的高度统计学显著结果，增强了我们发现的有效性。
