Friedrich Miescher Institute for Biomedical Research, CH-4058 Basel, Switzerland;
Genes Dev. 2013 Mar 15;27(6):581-9. doi: 10.1101/gad.207266.112.
lin-41 (lineage variant 41)/TRIM71 (tripartite motif 71) is well known for being a conserved target of the let-7 (lethal 7) microRNA (miRNA), a regulatory relationship found in animals evolutionarily as distant as Caenorhabditis elegans and humans. It has thus been studied extensively as a model for miRNA-mediated gene silencing. In contrast, the developmental and molecular functions of LIN41 have historically received less attention. However, LIN41 proteins are now emerging as important regulators of cell proliferation and differentiation in stem and progenitor cells. Moreover, LIN41's functions appear to involve two distinct molecular activities; namely, protein ubiquitylation and post-transcriptional silencing of mRNAs. Thus, LIN41 is ready for a scientific life of its own.
lin-41（谱系变体 41）/TRIM71（三部分基序 71）作为 let-7（致死 7）microRNA（miRNA）的保守靶标而广为人知，let-7 是一种在从秀丽隐杆线虫到人类等进化距离很远的动物中都存在的调控关系。因此，它被广泛研究作为 miRNA 介导的基因沉默的模型。相比之下，LIN41 的发育和分子功能在历史上受到的关注较少。然而，LIN41 蛋白现在作为干细胞和祖细胞中细胞增殖和分化的重要调节剂而出现。此外，LIN41 的功能似乎涉及两种不同的分子活性；即蛋白质泛素化和 mRNA 的转录后沉默。因此，LIN41 已经准备好开启它自己的科学生命。
