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RNA 结合蛋白和外切核酸酶在癌症中调节 miRNA：内部的敌人。

RNA-binding proteins and exoribonucleases modulating miRNA in cancer: the enemy within.

机构信息

Cancer Molecular Biology Branch, Research Institute, National Cancer Center, Goyang, 10408, Korea.

Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, 10408, Korea.

出版信息

Exp Mol Med. 2024 May;56(5):1080-1106. doi: 10.1038/s12276-024-01224-z. Epub 2024 May 1.

DOI:10.1038/s12276-024-01224-z
PMID:38689093
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11148060/
Abstract

Recent progress in the investigation of microRNA (miRNA) biogenesis and the miRNA processing machinery has revealed previously unknown roles of posttranscriptional regulation in gene expression. The molecular mechanistic interplay between miRNAs and their regulatory factors, RNA-binding proteins (RBPs) and exoribonucleases, has been revealed to play a critical role in tumorigenesis. Moreover, recent studies have shown that the proliferation of hepatocellular carcinoma (HCC)-causing hepatitis C virus (HCV) is also characterized by close crosstalk of a multitude of host RBPs and exoribonucleases with miR-122 and its RNA genome, suggesting the importance of the mechanistic interplay among these factors during the proliferation of HCV. This review primarily aims to comprehensively describe the well-established roles and discuss the recently discovered understanding of miRNA regulators, RBPs and exoribonucleases, in relation to various cancers and the proliferation of a representative cancer-causing RNA virus, HCV. These have also opened the door to the emerging potential for treating cancers as well as HCV infection by targeting miRNAs or their respective cellular modulators.

摘要

近年来，人们对 microRNA（miRNA）生物发生和 miRNA 加工机制的研究取得了进展，揭示了转录后调控在基因表达中的未知作用。miRNA 与其调控因子（RNA 结合蛋白（RBP）和外切核酸酶）之间的分子机制相互作用，被证明在肿瘤发生中起着关键作用。此外，最近的研究表明，导致肝细胞癌（HCC）的丙型肝炎病毒（HCV）的增殖也与大量宿主 RBP 和外切核酸酶与 miR-122 及其 RNA 基因组的密切串扰有关，这表明在 HCV 增殖过程中，这些因素之间的机制相互作用非常重要。本综述主要旨在全面描述 miRNA 调控因子、RBP 和外切核酸酶的既定作用，并讨论其在各种癌症和代表性致癌 RNA 病毒 HCV 增殖中的最新发现。这些研究也为通过靶向 miRNA 或其各自的细胞调节剂来治疗癌症和 HCV 感染开辟了新的途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3003/11148060/2e02a440cb18/12276_2024_1224_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3003/11148060/d73adb6f8725/12276_2024_1224_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3003/11148060/4644548415d3/12276_2024_1224_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3003/11148060/72b35cac791c/12276_2024_1224_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3003/11148060/4f6e147666a4/12276_2024_1224_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3003/11148060/4e7286d4572e/12276_2024_1224_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3003/11148060/cc93cefdebce/12276_2024_1224_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3003/11148060/389246eb04f6/12276_2024_1224_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3003/11148060/2e02a440cb18/12276_2024_1224_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3003/11148060/d73adb6f8725/12276_2024_1224_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3003/11148060/4644548415d3/12276_2024_1224_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3003/11148060/72b35cac791c/12276_2024_1224_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3003/11148060/4f6e147666a4/12276_2024_1224_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3003/11148060/4e7286d4572e/12276_2024_1224_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3003/11148060/cc93cefdebce/12276_2024_1224_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3003/11148060/389246eb04f6/12276_2024_1224_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3003/11148060/2e02a440cb18/12276_2024_1224_Fig8_HTML.jpg

相似文献

[1]
RNA-binding proteins and exoribonucleases modulating miRNA in cancer: the enemy within.

Exp Mol Med. 2024-5

[2]
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J Virol. 2016-6-24

[3]
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[4]
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[5]
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[6]
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Pharmacol Res. 2013-3-27

[7]
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[8]
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[9]
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Curr Opin Virol. 2014-8

[10]
Hepatitis B virus and microRNAs: Complex interactions affecting hepatitis B virus replication and hepatitis B virus-associated diseases.

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引用本文的文献

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Role of miRNA‑214‑3p in cancer (Review).

Oncol Rep. 2025-10

[2]
Unraveling the Role of the microRNA-Mediated Regulation of Actin-Binding Proteins in Ovarian Cancer: A Narrative Review.

Cancers (Basel). 2025-7-11

[3]
Three Siblings With an Attenuated Presentation of Perlman Syndrome: A Case Report and Literature Review.

Mol Genet Genomic Med. 2025-7

[4]
Targeting epigenetic regulators as a promising avenue to overcome cancer therapy resistance.

Signal Transduct Target Ther. 2025-7-18

[5]
Regulating the expression of exercise-induced micro-RNAs and long non-coding RNAs: implications for controlling cardiovascular diseases and heart failure.

Front Mol Biosci. 2025-5-20

[6]
Repression of ZNFX1 by LncRNA ZFAS1 mediates tobacco-induced pulmonary carcinogenesis.

Cell Mol Biol Lett. 2025-4-10

[7]
Deciphering the roles of non-coding RNAs in liposarcoma development: Challenges and opportunities for translational therapeutic advances.

Noncoding RNA Res. 2024-11-15

[8]
MicroRNAs and RNA-Binding Protein-Based Regulation of Bone Metastasis from Hepatobiliary Cancers and Potential Therapeutic Strategies.

Cells. 2024-11-21

[9]
Identification of a novel survival and immune microenvironment related ceRNA regulatory network for hepatocellular carcinoma based on circHECTD1.

Heliyon. 2024-6-27

本文引用的文献

[1]
Extracellular Vesicles from Cerebrospinal Fluid of Leptomeningeal Metastasis Patients Deliver MiR-21 and Induce Methotrexate Resistance in Lung Cancer Cells.

Int J Mol Sci. 2024-3-8

[2]
Cross-talk between PARN and EGFR-STAT3 Signaling Facilitates Self-Renewal and Proliferation of Glioblastoma Stem Cells.

Cancer Res. 2023-11-15

[3]
The RNA-binding protein KSRP aggravates malignant progression of clear cell renal cell carcinoma through transcriptional inhibition and post-transcriptional destabilization of the NEDD4L ubiquitin ligase.

J Biomed Sci. 2023-8-14

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DIS3L2 knockdown impairs key oncogenic properties of colorectal cancer cells via the mTOR signaling pathway.

Cell Mol Life Sci. 2023-6-20

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Sci Rep. 2023-3-31

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Arsenic resistance protein 2 and microRNA biogenesis: Biological implications in cancer development.

Pharmacol Ther. 2023-4

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Int J Mol Sci. 2023-2-17

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Proc Natl Acad Sci U S A. 2023-1-24

[9]
Targeting RNA Exonuclease XRN1 Potentiates Efficacy of Cancer Immunotherapy.

Cancer Res. 2023-3-15

[10]
DDX17 induces epithelial-mesenchymal transition and metastasis through the miR-149-3p/CYBRD1 pathway in colorectal cancer.

Cell Death Dis. 2023-1-2

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