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糖尿病药物治疗的风险与获益:2 型糖尿病药物治疗选择的合理方法。

Risk vs benefit in diabetes pharmacotherapy: a rational approach to choosing pharmacotherapy in type 2 diabetes.

机构信息

Medical Clinic of North Texas, 909 9th Ave, Ste 300, Fort Worth, TX 76104, USA.

出版信息

Curr Diab Rep. 2013 Jun;13(3):319-28. doi: 10.1007/s11892-013-0374-z.

DOI:10.1007/s11892-013-0374-z
PMID:23512666
Abstract

Type 2 diabetes now affects more than 1 in 10 US adults and is a leading cause of morbidity, mortality, and healthcare expense. There are increasing numbers of available pharmacotherapies, with established agents as well as newer drugs developed from hormones in the incretin pathway, among others. New data are accumulating continuously with respect to potential benefits of both long-standing and new agents, as well as risks identified through post-marketing surveillance. Here we review the commonly prescribed pharmacotherapy options with attention to recently published information and provide a rational approach to choice of therapy.

摘要

2 型糖尿病现在影响了超过 10%的美国成年人,是发病率、死亡率和医疗保健费用的主要原因。有越来越多的可用药物治疗方法,包括已确立的药物以及从肠促胰岛素途径等激素开发的新药。关于长期和新药物的潜在益处以及通过上市后监测发现的风险,新数据不断积累。在这里,我们回顾了常用的药物治疗选择,重点关注最近发表的信息,并提供了一种合理的治疗选择方法。

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Lancet. 2013 Jan 12;381(9861):117-24. doi: 10.1016/S0140-6736(12)61267-7. Epub 2012 Nov 7.
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A meta-analysis of serious adverse events reported with exenatide and liraglutide: acute pancreatitis and cancer.一项荟萃分析报告了 exenatide 和 liraglutide 的严重不良事件:急性胰腺炎和癌症。
Diabetes Res Clin Pract. 2012 Nov;98(2):271-84. doi: 10.1016/j.diabres.2012.09.008. Epub 2012 Sep 23.
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