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理解肠促胰岛素系统的历程:理论、实践,还有更多理论。

The journey to understanding incretin systems: Theory, practice and more theory.

机构信息

Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan.

Yutaka Seino Distinguished Center for Diabetes Research, Kansai Electric Power Medical Research Institute, Kobe, Japan.

出版信息

J Diabetes Investig. 2019 Sep;10(5):1171-1173. doi: 10.1111/jdi.13123. Epub 2019 Aug 20.

DOI:10.1111/jdi.13123
PMID:31361402
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6717807/
Abstract

Accumulating clinical data on incretin-based dipeptidyl peptidase-4 inhibitors and glucagon-like peptide-1 receptor agonists in the past decade have clearly confirmed their safety and efficacy as antidiabetes drugs. However, the journey to understand the incretin system and its role in health and disease continues.

摘要

在过去十年中,不断积累的基于肠促胰岛素的二肽基肽酶-4 抑制剂和胰高血糖素样肽-1 受体激动剂的临床数据,明确证实了它们作为抗糖尿病药物的安全性和有效性。然而,人们对肠促胰岛素系统及其在健康和疾病中的作用的认识仍在不断深入。

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本文引用的文献

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Bullous pemphigoid with dipeptidyl peptidase-4 inhibitors: Clinical features and pathophysiology.伴有二肽基肽酶-4 抑制剂的大疱性类天疱疮:临床特征和发病机制。
J Diabetes Investig. 2019 Sep;10(5):1168-1170. doi: 10.1111/jdi.13060. Epub 2019 May 14.
2
Alteration of gut microbiota by a Westernized lifestyle and its correlation with insulin resistance in non-diabetic Japanese men.西方化生活方式对肠道微生物群的改变及其与非糖尿病日本男性胰岛素抵抗的相关性。
J Diabetes Investig. 2019 Nov;10(6):1463-1470. doi: 10.1111/jdi.13048. Epub 2019 Apr 19.
3
Twincretin as a potential therapeutic for the management of type 2 diabetes with obesity.
Efficacy and safety of once-weekly semaglutide versus once-daily sitagliptin as add-on to metformin in patients with type 2 diabetes in SUSTAIN China: A 30-week, double-blind, phase 3a, randomized trial.
SUSTAIN China 研究:每周一次司美格鲁肽对比每日一次西格列汀作为二甲双胍添加治疗在中国 2 型糖尿病患者中的疗效和安全性:一项 30 周、双盲、3a 期、随机临床试验。
Diabetes Obes Metab. 2021 Feb;23(2):404-414. doi: 10.1111/dom.14232. Epub 2021 Jan 3.
双激素作为治疗肥胖 2 型糖尿病的潜在疗法。
J Diabetes Investig. 2019 Jul;10(4):902-905. doi: 10.1111/jdi.13005. Epub 2019 Feb 15.
4
Brown rice-specific γ-oryzanol as a promising prophylactic avenue to protect against diabetes mellitus and obesity in humans.糙米特异性γ-谷维素作为一种有前途的预防途径,可预防人类糖尿病和肥胖。
J Diabetes Investig. 2019 Jan;10(1):18-25. doi: 10.1111/jdi.12892. Epub 2018 Aug 21.
5
Relationship between deterioration of glycated hemoglobin-lowering effects in dipeptidyl peptidase-4 inhibitor monotherapy and dietary habits: Retrospective analysis of Japanese individuals with type 2 diabetes.二肽基肽酶-4 抑制剂单药治疗时糖化血红蛋白降低效果恶化与饮食习惯的关系:日本 2 型糖尿病患者的回顾性分析。
J Diabetes Investig. 2018 Sep;9(5):1153-1158. doi: 10.1111/jdi.12779. Epub 2017 Dec 26.
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Regulation of glucagon-like peptide-1 sensitivity by gut microbiota dysbiosis.肠道菌群失调对胰高血糖素样肽-1 敏感性的调节。
J Diabetes Investig. 2018 Mar;9(2):262-264. doi: 10.1111/jdi.12762. Epub 2017 Dec 1.
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J Diabetes Investig. 2018 Jan;9(1):21-24. doi: 10.1111/jdi.12718. Epub 2017 Sep 13.
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J Diabetes Investig. 2018 Jan;9(1):13-20. doi: 10.1111/jdi.12687. Epub 2017 Jun 12.
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J Diabetes Investig. 2018 Jan;9(1):25-32. doi: 10.1111/jdi.12681. Epub 2017 May 29.
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J Diabetes Investig. 2018 Jan;9(1):5-12. doi: 10.1111/jdi.12673. Epub 2017 May 24.