• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

使用硫化氢选择性探针鉴定胱硫醚β-合酶抑制剂。

Identification of cystathionine β-synthase inhibitors using a hydrogen sulfide selective probe.

机构信息

Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT 84112, USA.

出版信息

Angew Chem Int Ed Engl. 2013 Apr 22;52(17):4641-4. doi: 10.1002/anie.201300841. Epub 2013 Mar 19.

DOI:10.1002/anie.201300841
PMID:23512751
Abstract

Buzzing with activity: A hydrogen sulfide selective fluorogenic probe, 7-azido-4-methylcoumarin (AzMC), serves as a highly sensitive assay for cystathionine β-synthase activity, and is suitable for the high-throughput discovery of novel enzyme inhibitors.

摘要

充满活力

一种硫化氢选择性荧光探针，7-叠氮基-4-甲基香豆素（AzMC），可作为半胱氨酸β-合成酶活性的高灵敏度测定法，适用于新型酶抑制剂的高通量发现。

相似文献

1
Identification of cystathionine β-synthase inhibitors using a hydrogen sulfide selective probe.使用硫化氢选择性探针鉴定胱硫醚β-合酶抑制剂。
Angew Chem Int Ed Engl. 2013 Apr 22;52(17):4641-4. doi: 10.1002/anie.201300841. Epub 2013 Mar 19.
2
High-throughput tandem-microwell assay identifies inhibitors of the hydrogen sulfide signaling pathway.高通量串联微孔分析鉴定硫化氢信号通路抑制剂。
Chem Commun (Camb). 2013 Dec 28;49(100):11782-4. doi: 10.1039/c3cc46719h.
3
Marine natural products as inhibitors of cystathionine beta-synthase activity.作为胱硫醚β-合酶活性抑制剂的海洋天然产物。
Bioorg Med Chem Lett. 2015 Mar 1;25(5):1064-6. doi: 10.1016/j.bmcl.2015.01.013. Epub 2015 Jan 14.
4
A highly selective and fast-response fluorescent probe for visualization of enzymatic H2S production in vitro and in living cells.一种用于体外和活细胞中可视化酶促硫化氢生成的高选择性和快速响应荧光探针。
Chem Commun (Camb). 2015 Jul 4;51(52):10463-6. doi: 10.1039/c5cc03707g.
5
Screening of Heteroaromatic Scaffolds against Cystathionine Beta-Synthase Enables Identification of Substituted Pyrazolo[3,4-c]Pyridines as Potent and Selective Orthosteric Inhibitors.针对胱硫醚β-合酶的杂芳基支架筛选可鉴定取代的吡唑并[3,4-c]吡啶类化合物为强效和选择性的变构抑制剂。
Molecules. 2020 Aug 16;25(16):3739. doi: 10.3390/molecules25163739.
6
A Dual-Response Fluorescent Probe Reveals the H2 O2 -Induced H2 S Biogenesis through a Cystathionine β-Synthase Pathway.一种双响应荧光探针揭示了H2O2通过胱硫醚β-合酶途径诱导的H2S生物合成。
Chemistry. 2015 Oct 19;21(43):15167-72. doi: 10.1002/chem.201502832. Epub 2015 Sep 4.
7
A fluorogenic molecular nanoprobe with an engineered internal environment for sensitive and selective detection of biological hydrogen sulfide.一种具有工程化内部环境的荧光分子纳米探针，用于灵敏且选择性地检测生物硫化氢。
Chem Commun (Camb). 2017 Feb 14;53(14):2275-2278. doi: 10.1039/c6cc09696d.
8
The role of endogenous hydrogen sulfide in pathogenesis of chronotropic dysfunction in rats with cirrhosis.内源性硫化氢在肝硬化大鼠变时性功能障碍发病机制中的作用。
Eur J Pharmacol. 2012 Dec 5;696(1-3):130-5. doi: 10.1016/j.ejphar.2012.09.039. Epub 2012 Oct 5.
9
A near-infrared fluorescent turn-on probe for fluorescence imaging of hydrogen sulfide in living cells based on thiolysis of dinitrophenyl ether.基于二硝基苯醚的硫解反应用于活细胞中硫化氢荧光成像的近红外荧光开启探针。
Chem Commun (Camb). 2012 Nov 4;48(85):10529-31. doi: 10.1039/c2cc34031c.
10
Development of a highly selective fluorescence probe for hydrogen sulfide.硫化氢高选择性荧光探针的研制。
J Am Chem Soc. 2011 Nov 16;133(45):18003-5. doi: 10.1021/ja207851s. Epub 2011 Oct 25.

引用本文的文献

1
Enzymatic synthesis of azide by a promiscuous N-nitrosylase.一种混杂的N-亚硝基化酶催化合成叠氮化物
Nat Chem. 2024 Dec;16(12):2066-2075. doi: 10.1038/s41557-024-01646-2. Epub 2024 Sep 27.
2
Cellular turnover and degradation of the most common missense cystathionine beta-synthase variants causing homocystinuria.导致胱氨酸血症的最常见错义胱硫醚-β-合酶变体的细胞更替和降解。
Protein Sci. 2024 Aug;33(8):e5123. doi: 10.1002/pro.5123.
3
Architecture and regulation of filamentous human cystathionine beta-synthase.丝氨酸-β-内酰胺酶的结构和调控
Nat Commun. 2024 Apr 4;15(1):2931. doi: 10.1038/s41467-024-46864-x.
4
New insights into the regulation of , an enzyme involved in intellectual deficiency in Down syndrome.对一种与唐氏综合征智力缺陷有关的酶的调控的新见解。
Front Neurosci. 2023 Jan 9;16:1110163. doi: 10.3389/fnins.2022.1110163. eCollection 2022.
5
Implications of hydrogen sulfide in colorectal cancer: Mechanistic insights and diagnostic and therapeutic strategies.硫化氢在结直肠癌中的作用：机制见解及诊断与治疗策略。
Redox Biol. 2023 Feb;59:102601. doi: 10.1016/j.redox.2023.102601. Epub 2023 Jan 7.
6
A de novo protein catalyzes the synthesis of semiconductor quantum dots.一种从头合成的蛋白质可催化半导体量子点的合成。
Proc Natl Acad Sci U S A. 2022 Dec 20;119(51):e2204050119. doi: 10.1073/pnas.2204050119. Epub 2022 Dec 12.
7
Inorganic sulfur fixation via a new homocysteine synthase allows yeast cells to cooperatively compensate for methionine auxotrophy.通过一种新的同型半胱氨酸合酶进行无机硫固定，使酵母细胞能够协同补偿蛋氨酸营养缺陷型。
PLoS Biol. 2022 Dec 1;20(12):e3001912. doi: 10.1371/journal.pbio.3001912. eCollection 2022 Dec.
8
Recent therapeutic approaches to cystathionine beta-synthase-deficient homocystinuria.治疗胱硫醚β合酶缺乏型高胱氨酸尿症的新策略。
Br J Pharmacol. 2023 Feb;180(3):264-278. doi: 10.1111/bph.15991. Epub 2022 Dec 8.
9
HS biogenesis by cystathionine beta-synthase: mechanism of inhibition by aminooxyacetic acid and unexpected role of serine.半胱氨酸β-合酶介导的 HS 生物合成：氨基氧乙酸的抑制机制和丝氨酸的意外作用。
Cell Mol Life Sci. 2022 Jul 21;79(8):438. doi: 10.1007/s00018-022-04479-9.
10
Identification of 8-Hydroxyquinoline Derivatives That Decrease Cystathionine Beta Synthase (CBS) Activity.鉴定降低胱硫醚β合酶（CBS）活性的 8-羟基喹啉衍生物。
Int J Mol Sci. 2022 Jun 17;23(12):6769. doi: 10.3390/ijms23126769.