使用硫化氢选择性探针鉴定胱硫醚β-合酶抑制剂。
Identification of cystathionine β-synthase inhibitors using a hydrogen sulfide selective probe.
机构信息
Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT 84112, USA.
出版信息
Angew Chem Int Ed Engl. 2013 Apr 22;52(17):4641-4. doi: 10.1002/anie.201300841. Epub 2013 Mar 19.
PMID:23512751
Abstract
Buzzing with activity: A hydrogen sulfide selective fluorogenic probe, 7-azido-4-methylcoumarin (AzMC), serves as a highly sensitive assay for cystathionine β-synthase activity, and is suitable for the high-throughput discovery of novel enzyme inhibitors.
摘要
充满活力
一种硫化氢选择性荧光探针，7-叠氮基-4-甲基香豆素（AzMC），可作为半胱氨酸β-合成酶活性的高灵敏度测定法，适用于新型酶抑制剂的高通量发现。
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