Yavuz Celal, Caliskan Ahmet, Karahan Oguz, Demirtas Sinan, Yazici Suleyman
Vascular. 2014 Feb;22(1):42-5. doi: 10.1177/1708538112473978.
Thromboangiitis obliterans (TAO) affects small- and medium-sized vessels of the extremities via a non-atherosclerotic inflammatory process in the elderly. Although diagnostic criteria have been determined, only a few studies have been described in the laboratory features. Diagnostic biomarkers are important for reducing disruptions caused by TAO. The diagnostic importance of mean platelet volume (MPV) was investigated in TAO patients. Forty-four patients diagnosed with TAO (study group) and 45 healthy individuals (control group) were included in the study. The age, gender and complete blood parameters obtained via peripheral venous blood samples were compared between the two groups. A receiver operating characteristic (ROC) curve was used for determining the diagnostic accuracy of the MPV variable. All the variables were statistically similar in each group except MPV and platelet counts. MPV was significantly higher and platelet count was significantly lower in the TAO group (P< 0.05). In addition, diagnostic accuracy was measured by the area under the ROC curve (Figure 1), and MPV differs significantly (P< 0.001), with a value of 0.783 (95% CI: 0.711-0.854). This study indicates that MPV is probably an important diagnostic predictor in TAO patients. Detection of blood parameters such as platelet properties is important for meticulous care of these patients.
血栓闭塞性脉管炎（TAO）在老年人中通过非动脉粥样硬化性炎症过程影响四肢的中小血管。尽管已经确定了诊断标准，但关于实验室特征的研究却很少。诊断生物标志物对于减少TAO引起的干扰很重要。本研究调查了平均血小板体积（MPV）在TAO患者中的诊断意义。本研究纳入了44例诊断为TAO的患者（研究组）和45名健康个体（对照组）。比较了两组通过外周静脉血样本获得的年龄、性别和全血参数。采用受试者工作特征（ROC）曲线来确定MPV变量的诊断准确性。除MPV和血小板计数外，每组中的所有变量在统计学上均相似。TAO组的MPV显著更高，血小板计数显著更低（P<0.05）。此外，通过ROC曲线下面积测量诊断准确性（图1），MPV有显著差异（P<0.001），值为0.783（95%CI：0.711 - 0.854）。本研究表明，MPV可能是TAO患者重要的诊断预测指标。检测血小板特性等血液参数对于精心护理这些患者很重要。
