Department of Internal Medicine, Gaziosmanpasa University, Tokat, Turkey.
Department of Cardiovascular Surgery, Tokat State Hospital, Tokat, Turkey.
Int J Clin Pract. 2022 Jan 31;2022:9347946. doi: 10.1155/2022/9347946. eCollection 2022.
Raynaud's phenomenon (RP) is a multifactorial disorder. If any underlying disease cannot be determined to be responsible for RP, then it is considered to be the primary RP (pRP). We aimed to investigate the differences between laboratory markers and impaired endothelial function in pRP.
Forty-two pRP patients and 30 healthy individuals were included as the study and control groups, respectively. The endothelial function was evaluated with flow-mediated dilatation (FMD) of the brachial artery. The blood samples were obtained from both groups, and white blood cell (WBC), hemoglobin, platelets, mean platelet volume (MPV), creatinine, alanine aminotransferase (ALT), aspartate aminotransferase (AST), D-dimer, fibrinogen, albumin, fibrinogen-to-albumin ratio (FAR), neutrophil-to-lymphocyte ratio (NLR), D-dimer-to-albumin ratio (DDAR), and monocyte chemoattractant protein-1 (MCP-1) parameters were studied. The blood parameters and FMD values obtained were compared between groups.
The groups were similar in regard to age, gender, and smoking history ( < 0.05). There was no difference between the two groups in regard to hemoglobin, platelet, MPV, creatinine, ALT, D-dimer, albumin, FAR, NLR, and DDAR levels ( < 0.05). AST levels were slightly higher in the pRP group (=0.027). Markedly increased WBC, fibrinogen, MPV, and MCP-1 values were detected in the pRP group (=0.001), as well as higher abnormal FMD responses (=0.001). There was a direct correlation between abnormal FMD response and serum MCP-1 values in patients with pRP (: 0.308, : 0.095, : 0.044).
It seems to be that MCP-1 levels are higher in patients with pRP, and increased values of MCP-1 levels seem to be related to impaired endothelial functions.
雷诺现象（RP）是一种多因素疾病。如果不能确定任何潜在疾病是导致 RP 的原因，则将其视为原发性 RP（pRP）。我们旨在研究 pRP 患者的实验室标志物和内皮功能障碍之间的差异。
将 42 例 pRP 患者和 30 名健康个体分别纳入研究组和对照组。肱动脉血流介导的扩张（FMD）评估内皮功能。从两组采集血样，研究白细胞（WBC）、血红蛋白、血小板、平均血小板体积（MPV）、肌酐、丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、D-二聚体、纤维蛋白原、白蛋白、纤维蛋白原与白蛋白比值（FAR）、中性粒细胞与淋巴细胞比值（NLR）、D-二聚体与白蛋白比值（DDAR）和单核细胞趋化蛋白-1（MCP-1）参数。比较两组间的血液参数和 FMD 值。
两组在年龄、性别和吸烟史方面相似（<0.05）。两组在血红蛋白、血小板、MPV、肌酐、ALT、D-二聚体、白蛋白、FAR、NLR 和 DDAR 水平方面无差异（<0.05）。AST 水平在 pRP 组略高（=0.027）。pRP 组的 WBC、纤维蛋白原、MPV 和 MCP-1 值显著升高（=0.001），异常 FMD 反应也较高（=0.001）。pRP 患者异常 FMD 反应与血清 MCP-1 值呈直接相关（：0.308，：0.095，：0.044）。
似乎 pRP 患者的 MCP-1 水平较高，并且 MCP-1 水平的升高似乎与内皮功能障碍有关。
