Mokuno H, Yamada N, Sugimoto T, Kobayashi T, Ishibashi S, Shimano H, Takizawa M, Kawakami M, Takaku F, Murase T
Third Department of Internal Medicine, University of Tokyo, Japan.
Horm Metab Res. 1990 Apr;22(4):246-51. doi: 10.1055/s-2007-1004894.
We have studied the effect of diet therapy on plasma lipoprotein metabolism in heterozygous familial hypercholesterolemia. Seven patients with a mean plasma cholesterol concentration of 323 +/- 67 mg/dl were hospitalized and kept on a cholesterol-free diet for as long as 11 days without any medication. The content of dietary cholesterol was approximately 1.4 mg a day, and dietary fat, carbohydrate and protein comprised 18.0, 69.2 and 12.8% of calories, respectively. The ratio of polyunsaturated to saturated fatty acids (P/S) was 3.1. At the end of the study period, plasma cholesterol was lowered by 14.2%, from 323 to 277 mg/dl, and low density lipoprotein (LDL) cholesterol by 17.5% from 229 to 189 mg/dl. Using density gradient ultracentrifugation, the major change in LDL cholesterol was found to be in those fractions with a mean density between 1.034 and 1.042, where cholesterol concentrations decreased from 132 to 87 mg/dl (34%). These results indicate that diet therapy with free-cholesterol and a high ratio of P/S is highly effective in controlling plasma cholesterol levels in heterozygous familial hypercholesterolemia.
我们研究了饮食疗法对杂合子家族性高胆固醇血症患者血浆脂蛋白代谢的影响。7名平均血浆胆固醇浓度为323±67mg/dl的患者住院，在未服用任何药物的情况下，持续11天采用无胆固醇饮食。饮食中胆固醇含量约为每天1.4mg，饮食中的脂肪、碳水化合物和蛋白质分别占热量的18.0%、69.2%和12.8%。多不饱和脂肪酸与饱和脂肪酸的比例（P/S）为3.1。在研究期结束时，血浆胆固醇从323mg/dl降至277mg/dl，降低了14.2%，低密度脂蛋白（LDL）胆固醇从229mg/dl降至189mg/dl，降低了17.5%。采用密度梯度超速离心法发现，LDL胆固醇的主要变化发生在平均密度为1.034至1.042的组分中，其中胆固醇浓度从132mg/dl降至87mg/dl（降低了34%）。这些结果表明，无胆固醇且P/S比值高的饮食疗法对控制杂合子家族性高胆固醇血症患者的血浆胆固醇水平非常有效。
