Department of Physiotherapy, School of Health Sciences, The University of Melbourne, Melbourne, Victoria, Australia.
BMC Cancer. 2013 Mar 20;13:135. doi: 10.1186/1471-2407-13-135.
The measurement properties of instruments used to assess functional capacity, physical activity and muscle strength in participants with non-small cell lung cancer (NSCLC) have not been systematically reviewed.
To identify outcome measures used to assess these outcomes in participants with NSCLC; and to evaluate, synthesise and compare the measurement properties of the outcome measures identified.
A systematic review of articles using electronic databases MEDLINE (1950-2012), CINAHL (1982-2012), EMBASE (1980-2012), Cochrane Library (2012), Expanded Academic ASAP (1994-2012), Health Collection Informit (1995-2012) and PEDRO (1999-2012). Additional studies were identified by searching personal files and cross referencing. Eligibility Criteria for Study Selection: Search one: studies which assessed functional capacity, physical activity or muscle strength in participants with NSCLC using non-laboratory objective tests were included. Search two: studies which evaluated a measurement property (inter- or intra-rater reliability; measurement error; criterion or construct validity; or responsiveness) in NSCLC for one of the outcome measures identified in search one. Studies published in English from 1980 were eligible. Data Extraction and Methodological Quality Assessment: data collection form was developed and data extracted. Methodological quality of studies was assessed by two independent reviewers using the 4-point COSMIN checklist.
Thirteen outcome measures were identified. Thirty-one studies evaluating measurement properties of the outcome measures in participants with NSCLC were included. Functional capacity was assessed using the six- and twelve-minute walk tests; incremental- and endurance-shuttle walk tests; and the stair-climbing test. Criterion validity for three of these measures was established in NSCLC but not the reliability or responsiveness. Physical activity was measured using accelerometers and pedometers. Only the construct validity for accelerometers and pedometers was reported. Muscle strength was measured using hand-held dynamometry, hand-grip dynamometry, manual muscle test, one-repetition maximum and the chair-stand test, however only two studies reported reliability and measurement error and one study reported construct validity.
Currently there is a gap in the literature regarding the measurement properties of commonly used outcome measures in NSCLC participants, particularly reliability, measurement error and responsiveness. Further research needs to be conducted to determine the most suitable outcome measures for use in trials involving NSCLC participants.
目前尚无系统评价评估非小细胞肺癌（NSCLC）患者功能能力、身体活动和肌肉力量的测量工具的测量性能。
确定用于评估 NSCLC 患者这些结果的测量指标；评估、综合和比较确定的测量指标的测量性能。
对使用电子数据库 MEDLINE（1950-2012 年）、CINAHL（1982-2012 年）、EMBASE（1980-2012 年）、Cochrane 图书馆（2012 年）、扩展学术 ASAP（1994-2012 年）、Health Collection Informit（1995-2012 年）和 PEDRO（1999-2012 年）的文章进行了系统评价。通过搜索个人档案和交叉引用，还确定了其他研究。研究入选标准：搜索 1：使用非实验室客观测试评估 NSCLC 患者功能能力、身体活动或肌肉力量的研究。搜索 2：评估搜索 1 中确定的测量指标之一的 NSCLC 中测量性能（内部或外部评分者信度；测量误差；标准或构念效度；或反应性）的研究。从 1980 年开始发表的英文研究都符合条件。
制定数据收集表并提取数据。两位独立评审员使用 4 点 COSMIN 清单评估研究的方法学质量。
确定了 13 种测量指标。共纳入 31 项评估 NSCLC 患者测量指标的测量性能的研究。使用 6 分钟和 12 分钟步行测试、递增和耐力穿梭步行测试以及爬楼梯测试评估功能能力。这些措施中的三项的标准效度已在 NSCLC 中确立，但可靠性或反应性尚未确定。身体活动使用加速度计和计步器进行测量。仅报道了加速度计和计步器的构念效度。肌肉力量使用手持测力计、握力测力计、手动肌肉测试、一次重复最大和椅站测试进行测量，但只有两项研究报告了可靠性和测量误差，一项研究报告了构念效度。
目前，关于 NSCLC 患者常用测量指标的测量性能的文献存在空白，特别是可靠性、测量误差和反应性。需要进一步研究以确定最适合用于涉及 NSCLC 患者的试验的测量指标。
