Basel Matthew T, Balivada Sivasai, Beck Amanda P, Kerrigan Maureen A, Pyle Marla M, Dekkers Jack C M, Wyatt Carol R, Rowland Robert R R, Anderson David E, Bossmann Stefan H, Troyer Deryl L
Department of Anatomy and Physiology, Kansas State University , Manhattan, Kansas.
Biores Open Access. 2012 Apr;1(2):63-8. doi: 10.1089/biores.2012.9902.
Animal models for cancer therapy are invaluable for preclinical testing of potential cancer treatments; however, therapies tested in such models often fail to translate into clinical settings. Therefore, a better preclinical model for cancer treatment testing is needed. Here we demonstrate that an immunodeficient line of pigs can host and support the growth of xenografted human tumors and has the potential to be an effective animal model for cancer therapy. Wild-type and immunodeficient pigs were injected subcutaneously in the left ear with human melanoma cells (A375SM cells) and in the right ear with human pancreatic carcinoma cells (PANC-1). All immunodeficient pigs developed tumors that were verified by histology and immunohistochemistry. Nonaffected littermates did not develop tumors. Immunodeficient pigs, which do not reject xenografted human tumors, have the potential to become an extremely useful animal model for cancer therapy because of their similarity in size, anatomy, and physiology to humans.
癌症治疗的动物模型对于潜在癌症治疗方法的临床前测试非常重要；然而，在此类模型中测试的治疗方法往往无法转化到临床环境中。因此，需要一种更好的癌症治疗测试临床前模型。在此，我们证明了一种免疫缺陷猪品系能够容纳并支持异种移植的人类肿瘤生长，并且有潜力成为一种有效的癌症治疗动物模型。将野生型和免疫缺陷猪的左耳皮下注射人黑色素瘤细胞（A375SM细胞），右耳皮下注射人胰腺癌细胞（PANC-1）。所有免疫缺陷猪都长出了经组织学和免疫组织化学验证的肿瘤。未受影响的同窝仔猪未长出肿瘤。不排斥异种移植人类肿瘤的免疫缺陷猪，因其在大小、解剖结构和生理机能上与人类相似，有潜力成为一种极其有用的癌症治疗动物模型。
