发育中的多形细胞和髓鞘修复。
Polydendrocytes in development and myelin repair.
机构信息
Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269-3156, USA.
出版信息
Neurosci Bull. 2013 Apr;29(2):165-76. doi: 10.1007/s12264-013-1320-4. Epub 2013 Mar 20.
Abstract
Polydendrocytes (NG2 cells) are a distinct type of glia that populate the developing and adult central nervous systems (CNS). In the adult CNS, they retain mitotic activity and represent the largest proliferating cell population. Genetic and epigenetic mechanisms regulate the fate of polydendrocytes, which give rise to both oligodendrocytes and astrocytes. In addition, polydendrocytes actively differentiate into myelin-forming oligodendrocytes in response to demyelination. This review summarizes the current knowledge regarding polydendrocyte development, which provides an important basis for understanding the mechanisms that lead to the remyelination of demyelinated lesions.
摘要
少突胶质前体细胞（NG2 细胞）是一种独特的神经胶质细胞类型，存在于中枢神经系统（CNS）的发育和成年阶段。在成年 CNS 中，它们保持有丝分裂活性，是最大的增殖细胞群体。遗传和表观遗传机制调控少突胶质前体细胞的命运，使其分化为少突胶质细胞和星形胶质细胞。此外，少突胶质前体细胞在脱髓鞘时可主动分化为形成髓鞘的少突胶质细胞。本综述总结了少突胶质前体细胞发育的最新知识，为理解导致脱髓鞘病变髓鞘再生的机制提供了重要基础。
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