Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Straße, Greifswald, 17475, Germany.
BMC Endocr Disord. 2013 Mar 21;13:12. doi: 10.1186/1472-6823-13-12.
To investigate potential associations of serum prolactin concentration (PRL) with metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM), previously observed in small and selected study samples, in a large population-based cohort.
Data from 3,993 individuals (2,027 women) aged 20-79 years from the population-based Study of Health of Pomerania (SHIP) were used to analyse cross-sectional and longitudinal associations of PRL with MetS and T2DM risk in age- and multivariable-adjusted Poisson regression models. PRL were log-transformed and modelled as continuous (per standard deviation (SD) increase) and categorical predictor (sex-specific quartiles) variable, separately for men and woman.
Cross-sectional analyses showed an inverse association between low PRL concentrations and prevalent T2DM risk in men and women after multivariable-adjustment (men: Q1 vs. Q4: relative risk (RR), 1.55; 95% confidence interval (CI), 1.13 - 2.14; women: Q1 vs. Q4: RR, 1.70; 95% CI, 1.10 - 2.62). Likewise, higher PRL concentrations were associated with significantly lower T2DM risk (RR per SD increase in log-PRL: 0.83; 95% CI, 0.72 - 0.95 in men, and 0.84; 95% CI, 0.71 - 0.98 in women, respectively). An inverse association between PRL and MetS risk was not retained after multivariable adjustment. Longitudinal analyses yielded no association of PRL with incident MetS or T2DM.
The present study is the first large population-based study reporting a cross-sectional inverse association between PRL and prevalent T2DM in both genders. But the absent longitudinal associations do not support a causal role of PRL as a risk factor of incident MetS or T2DM.
为了研究催乳素浓度（PRL）与代谢综合征（MetS）和 2 型糖尿病（T2DM）之间的潜在关联，我们在一个大型基于人群的队列中对以前在小样本和选定的研究样本中观察到的这些关联进行了研究。
我们使用来自基于人群的波罗的海健康研究（SHIP）的 3993 名年龄在 20-79 岁的个体（2027 名女性）的数据，在年龄和多变量调整的泊松回归模型中分析了 PRL 与 MetS 和 T2DM 风险的横断面和纵向关联。将 PRL 进行对数转换，并分别以男性和女性为研究对象，以连续（按标准偏差（SD）增加）和分类预测变量（性别特异性四分位数）变量的形式进行建模。
横断面分析显示，在多变量调整后，男性和女性的低 PRL 浓度与 T2DM 发病风险呈负相关（男性：Q1 与 Q4 相比，相对风险（RR）为 1.55；95%置信区间（CI）为 1.13-2.14；女性：Q1 与 Q4 相比，RR 为 1.70；95%CI 为 1.10-2.62）。同样，较高的 PRL 浓度与 T2DM 发病风险显著降低相关（每增加一个 SD 的 log-PRL，RR 为 0.83；95%CI，男性为 0.72-0.95，女性为 0.84；95%CI，0.71-0.98）。多变量调整后，PRL 与 MetS 风险之间的关联不再保留。纵向分析未显示 PRL 与新发 MetS 或 T2DM 之间存在关联。
本研究是第一项大型基于人群的研究，报告了 PRL 与两性 T2DM 之间的横断面负相关。但不存在纵向关联并不支持 PRL 作为 MetS 或 T2DM 发病风险因素的因果作用。
