Department of Chemistry, Renmin University of China, Beijing 100872, China.
Chem Commun (Camb). 2013 May 4;49(34):3552-4. doi: 10.1039/c3cc41258j.
Gold(I) catalyzed [3+2] cycloaddition of azomethine imines with N-allenyl amides was developed to provide two types of pyrazolyl based bicyclic heterocycles. Both pyrazolidin-3-one derived and dihydroisoquinoline derived azomethine imines reacted smoothly with N-allenyl amides to give 6-methylene bipyrazolidin-1-ones and 1-methylene hexahydropyrazolo[5,1-a] isoquinolines in moderate to good yields.
金（I）催化的偕亚胺腙与 N-烯丙基酰胺的[3+2]环加成反应被开发用于提供两种类型的吡唑基双环杂环。吡唑烷-3-酮衍生的和二氢异喹啉衍生的偕亚胺腙与 N-烯丙基酰胺反应均能以中等至良好的收率得到 6-亚甲基双吡唑烷-1-酮和 1-亚甲基六氢吡唑并[5,1-a]异喹啉。
