Bernal-Albert Paloma, Faustino Hélio, Gimeno Ana, Asensio Gregorio, Mascareñas José L, López Fernando
Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS) and Departamento de Química Orgánica, Universidad de Santiago de Compostela , 15782, Santiago de Compostela, Spain.
Org Lett. 2014 Dec 5;16(23):6196-9. doi: 10.1021/ol503121q. Epub 2014 Nov 19.
α,β-Unsaturated N,N-dialkyl hydrazones undergo a mild [2 + 2] cycloaddition to allenamides when treated with a suitable gold catalyst. The method, which represents the first application of N,N-dialkyl hydrazones in gold catalysis, is compatible with a wide variety of substituents at the alkenyl moiety of the hydrazone component, proceeds with excellent levels of regio- and diastereoselectivity, and provides densely substituted cyclobutanes with good to excellent yields.
当用合适的金催化剂处理时，α,β-不饱和N,N-二烷基腙与烯丙酰胺发生温和的[2 + 2]环加成反应。该方法是N,N-二烷基腙在金催化中的首次应用，与腙组分烯基部分的多种取代基兼容，具有优异的区域和非对映选择性，并且能以良好至优异的产率提供高度取代的环丁烷。
