CD31的分子克隆，CD31是一种与癌胚抗原密切相关的假定细胞间粘附分子。
Molecular cloning of CD31, a putative intercellular adhesion molecule closely related to carcinoembryonic antigen.
作者信息
Simmons D L, Walker C, Power C, Pigott R
机构信息
Imperial Cancer Research Fund, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, United Kingdom.
出版信息
J Exp Med. 1990 Jun 1;171(6):2147-52. doi: 10.1084/jem.171.6.2147.
Abstract
cDNA clones encoding CD31 have been isolated by transient expression. The sequence of CD31 expressed on human umbilical vein endothelial cells (HUVEC) is identical to that expressed on the monocyte-like cell line HL60. In HUVEC. CD31 is concentrated in regions of cell-cell contacts. CD31 is a member of the Ig superfamily and is most closely related to the carcinoembryonic antigen CEA, consisting of four contiguous C2 domains. The localization of CD31 to regions of cell-cell contacts, and the sequence similarity to CEA, a known intercellular adhesion molecule (ICAM), strongly suggest that CD31 may function as an ICAM, possibly mediating endothelial cell-cell contacts and also promoting interactions between leukocytes and endothelial cells.
摘要
通过瞬时表达已分离出编码CD31的cDNA克隆。在人脐静脉内皮细胞（HUVEC）上表达的CD31序列与在单核细胞样细胞系HL60上表达的序列相同。在HUVEC中，CD31集中在细胞间接触区域。CD31是免疫球蛋白超家族的成员，与癌胚抗原CEA关系最为密切，由四个相邻的C2结构域组成。CD31定位于细胞间接触区域，以及与已知的细胞间粘附分子（ICAM）CEA的序列相似性，强烈表明CD31可能作为一种ICAM发挥作用，可能介导内皮细胞间接触，并促进白细胞与内皮细胞之间的相互作用。
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