Stoller Jason Z, Demauro Sara B, Dagle John M, Reese Jeff
Department of Pediatrics, University of Pennsylvania School of Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
J Clin Exp Cardiolog. 2012 Jun 15;8(1). doi: 10.4172/2155-9880.S8-001.
The ductus arteriosus (DA) shunts blood away from the lungs during fetal life, but at birth this shunt is no longer needed and the vessel rapidly constricts. Postnatal persistence of the DA, patent ductus arteriosus (PDA), is predominantly a detrimental condition for preterm infants but is simultaneously a condition required to maintain systemic blood flow for infants born with certain severe congenital heart defects. Although PDA in preterm infants is associated with significant morbidities, there is controversy regarding whether PDA is truly causative. Despite advances in our understanding of the pathobiology of PDA, the optimal treatment strategy for PDA in preterm infants is unclear. Here we review recent studies that have continued to elucidate the fundamental mechanisms of DA development and pathogenesis.
动脉导管（DA）在胎儿期将血液分流至肺外，但出生时这种分流不再需要，该血管迅速收缩。动脉导管出生后持续存在，即动脉导管未闭（PDA），主要对早产儿是一种有害状况，但同时对于患有某些严重先天性心脏病的婴儿而言，它是维持体循环血流所必需的状况。尽管早产儿的PDA与显著的发病率相关，但PDA是否真的是病因仍存在争议。尽管我们对PDA的病理生物学的理解有所进展，但早产儿PDA的最佳治疗策略仍不明确。在此，我们综述了近期持续阐明DA发育和发病机制的基础研究。
