Department of Medicine, Queen's University, Kingston, Ontario, Canada.
QCPU, Queen's Cardiopulmonary Unit, Translational Institute of Medicine (TIME), Department of Medicine, Queen's University, Canada; Department of Medicine, Queen's University, Kingston, Ontario, Canada.
Semin Perinatol. 2023 Mar;47(2):151715. doi: 10.1016/j.semperi.2023.151715. Epub 2023 Mar 2.
The ductus arteriosus (DA) connects the aorta to the pulmonary artery (PA), directing placentally oxygenated blood away from the developing lungs. High pulmonary vascular resistance and low systemic vascular resistance facilitate shunting of blood in utero from the pulmonary to the systemic circulation through the widely patent DA, thereby optimizing fetal oxygen (O) delivery. With the transition from fetal (hypoxia) to neonatal (normoxia) oxygen conditions, the DA constricts while the PA dilates. This process often fails in prematurity, promoting congenital heart disease. Impaired O-responsivness in the DA promotes persistent ductus arteriosus (PDA), the most common form of congenital heart disease. Knowledge of DA oxygen sensing has greatly advanced in the past few decades, however we still lack a complete understanding of the sensing mechanism. The genomic revolution of the past two decades has facilitated unprecedented discovery in every biological system. This review will demonstrate how multiomic integration of data generated from the DA can breathe new life into our understanding of the DA's oxygen response.
动脉导管（DA）连接主动脉和肺动脉（PA），将来自胎盘的含氧血液从发育中的肺部带走。高肺血管阻力和低体循环血管阻力有助于在子宫内通过广泛开放的 DA 将血液从肺循环分流到体循环，从而优化胎儿的氧气（O）输送。随着从胎儿（缺氧）到新生儿（正常氧）的氧条件的转变，DA 收缩而 PA 扩张。在早产的情况下，这个过程通常会失败，从而促进先天性心脏病的发生。DA 中的 O 反应受损会导致持续性动脉导管未闭（PDA），这是最常见的先天性心脏病形式。过去几十年中，DA 中的氧感应知识有了很大的进步，但我们仍然缺乏对感应机制的完整理解。过去二十年的基因组革命促进了每个生物系统中前所未有的发现。这篇综述将展示如何通过整合来自 DA 的多组学数据，为我们理解 DA 的氧反应带来新的活力。
