Center for Advanced Neurological Research, KS Hegde Medical Academy, Nitte University, India.
Mult Scler. 2013 Oct;19(12):1592-6. doi: 10.1177/1352458513482375. Epub 2013 Mar 21.
Vitamin D deficiency is widely prevalent in India. The association between vitamin D status and multiple sclerosis (MS) has not been previously studied in Indians.
The objective of this paper is to determine whether vitamin D status is associated with MS in India.
In this study 110 MS patients and 108 matched controls were included. Serum 25-hydroxyvitamin D (25(OH)D) was measured in 63 patients in relapse, 77 patients in remission and all controls. Quantity of sun exposure in childhood and body mass index (BMI) were calculated. Patients and controls were genotyped for HLA-DRB1*1501.
Patients had significantly lower 25(OH)D levels than matched controls (p = 0.003), and patients in relapse had a significantly lower vitamin D level as compared to those in remission (p = 0.001). Vitamin D deficiency (< 50 nmol/l) was seen in a higher proportion of cases (71.8%) than controls (53.7%) (p = 0.01). Higher quartiles of vitamin D (> 58 nmol/l) showed an inverse relationship with MS (OR = 0.28, CI = 0.11-0.68, p= 0.005). This effect persisted after adjusting for sun exposure.
The results of our study indicated that serum 25(OH)D shows an inverse relationship with MS in the Indian population. Reverse causality cannot be excluded.
印度普遍存在维生素 D 缺乏症。维生素 D 状态与多发性硬化症 (MS) 之间的关联以前尚未在印度人群中进行过研究。
本文旨在确定维生素 D 状态是否与印度的 MS 相关。
本研究纳入了 110 名 MS 患者和 108 名匹配对照。在 63 名处于复发期的患者、77 名处于缓解期的患者和所有对照中测量了血清 25-羟维生素 D (25(OH)D)。计算了儿童时期的阳光暴露量和体重指数 (BMI)。对患者和对照进行了 HLA-DRB1*1501 基因分型。
患者的 25(OH)D 水平明显低于匹配对照 (p = 0.003)，且复发期患者的维生素 D 水平明显低于缓解期患者 (p = 0.001)。病例组中维生素 D 缺乏症（<50 nmol/l）的比例明显高于对照组（71.8%比 53.7%）(p = 0.01)。较高的维生素 D 四分位数 (>58 nmol/l)与 MS 呈负相关（OR = 0.28，CI = 0.11-0.68，p= 0.005）。调整阳光暴露后，这种相关性仍然存在。
我们的研究结果表明，血清 25(OH)D 与印度人群中的 MS 呈负相关。不能排除反向因果关系。
