Department of Clinical Research, National Center for Global Health and Medicine, Tokyo, Japan.
Obesity (Silver Spring). 2014 Jan;22(1):287-91. doi: 10.1002/oby.20425. Epub 2013 Jun 11.
To examine the combined effect of CT-measured visceral fat area (VFA) and adiponectin level against the clustering of metabolic risk factors.
The subjects were 6,996 Japanese. The subjects were divided according to the combinations of VFA and adiponectin level quartiles and the odds ratio for multiple risk factors of metabolic syndrome were calculated (adjusted for age and lifestyle factors using logistic regression analyses). Group with the lowest VFA and the highest adiponectin level was used as a reference. The correlation between adiponectin level and each metabolic risk factor was evaluated.
The strongest correlation was observed between adiponectin level and high-density lipoprotein cholesterol levels (r = 0.369 and 0.439 for men and women). Both VFA and adiponectin level were independently associated with the clustering of metabolic risk factors (interaction P = 0.58 and 0.11 for men and women). The odds ratio for the clustering of metabolic risk factors in the group with the highest VFA and the lowest adiponectin level, compared with the group with the lowest VFA and the highest adiponectin level, was 12.7 (9.7-16.6) for men and 13.5 (6.0-30.2) for women.
The ability to detect metabolic syndrome could be improved by examining adiponectin level in conjunction with VFA.
探讨 CT 测量的内脏脂肪面积（VFA）与脂联素水平联合对代谢危险因素聚集的影响。
本研究对象为 6996 名日本人。根据 VFA 和脂联素四分位水平的组合将受试者进行分组，并计算代谢综合征多种危险因素的比值比（采用 logistic 回归分析，校正年龄和生活方式因素）。以 VFA 和脂联素水平最低的组作为参考。评估脂联素水平与各代谢危险因素之间的相关性。
脂联素水平与高密度脂蛋白胆固醇水平之间存在最强的相关性（男性和女性的 r 值分别为 0.369 和 0.439）。VFA 和脂联素水平均与代谢危险因素聚集独立相关（男性和女性的交互 P 值分别为 0.58 和 0.11）。与 VFA 和脂联素水平最低的组相比，VFA 最高和脂联素水平最低的组发生代谢危险因素聚集的比值比为 12.7（9.7-16.6），女性为 13.5（6.0-30.2）。
通过同时检查 VFA 和脂联素水平，可以提高对代谢综合征的检测能力。
