Department of Cardiovascular Medicine, The University of Tokyo Hospital, Tokyo, Japan.
Department of Clinical Laboratory, The University of Tokyo Hospital, Tokyo, Japan.
Sci Rep. 2019 Mar 14;9(1):4435. doi: 10.1038/s41598-018-37137-x.
We evaluated the association between visceral adiposity and left ventricular (LV) diastolic function in association with plasma adiponectin levels in 213 subjects without overt cardiac diseases. Abdominal visceral fat area was quantified by computed tomography. Excessive visceral fat was significantly associated with impaired diastolic parameters including E/A, E' and E/E'. Although serum adiponectin levels decreased with increased visceral adiposity, there was no independent association between serum adiponectin levels and diastolic parameters, which suggest that the role of adiponectin in this association might be indirect.
我们在 213 名无明显心脏疾病的受试者中评估了内脏脂肪与左心室（LV）舒张功能的关系，并与血浆脂联素水平相关联。通过计算机断层扫描定量腹部内脏脂肪面积。过多的内脏脂肪与舒张功能参数（包括 E/A、E'和 E/E'）受损显著相关。尽管血清脂联素水平随内脏脂肪增加而降低，但血清脂联素水平与舒张功能参数之间无独立相关性，这表明脂联素在这种关联中的作用可能是间接的。
