Eviderm Institute AB, Solna, Sweden.
Skin Res Technol. 2013 Nov;19(4):438-45. doi: 10.1111/srt.12066. Epub 2013 Mar 22.
Moisturizers are often used to overcome dry skin conditions. However, cosmetic moisturizers may lack in efficiency and may also deteriorate skin barrier function. The objective of this study was to generate data on a new humectant-rich formulation (15% alfahydroxy acids and 15% urea) in the treatment of normal skin as well as in dry feet with hyperkeratosis and cracked skin with fissures. Changes in permeability and effectiveness of the product after once- and twice-daily applications to the feet will be monitored.
The study was randomized, bilateral, controlled and evaluator-blind. The first part of the study included 12 healthy volunteers and the second part 50 patients with hyperkeratotic feet. The changes in the skin was evaluated by an expert, the patients and using non-invasive biophysical measurements of skin barrier function (transepidermal water loss, TEWL), erythema, thickness (ultrasound) and hydration (conductance).
The humectant-rich formulation increased skin hydration, removed scales and reduced thickness of hyperkeratotic skin. Skin barrier function was improved in normal skin, but no changes in TEWL were noted in the feet. No difference between once and twice-daily applications was found. Some smarting and stinging was noted.
The humectant-rich formulation efficiently relieved the xerosis on the feet without inducing any weakening of the skin barrier function. Instead the normal skin became more resistant to external insults by the treatment.
保湿剂常用于缓解皮肤干燥状况。然而，化妆品保湿剂可能效率较低，还可能使皮肤屏障功能恶化。本研究旨在为一种新型保湿剂丰富配方（15%α-羟基酸和 15%尿素）在正常皮肤以及伴有过度角化、干裂的干燥足部的治疗方面提供数据。将监测该产品每日一次和两次应用于足部后的通透性和功效变化。
该研究为随机、双侧、对照和评估者盲法研究。研究的第一部分纳入 12 名健康志愿者，第二部分纳入 50 名伴有过度角化足部的患者。皮肤变化由专家、患者以及使用皮肤屏障功能的非侵入性生物物理测量（经表皮水分流失，TEWL）、红斑、厚度（超声）和水合作用（电导率）进行评估。
富含保湿剂的配方增加了皮肤水分，去除了鳞屑并减少了过度角化皮肤的厚度。正常皮肤的屏障功能得到改善，但足部 TEWL 无变化。每日一次和两次应用之间没有差异。有一些刺痛和灼痛感。
富含保湿剂的配方能有效缓解足部干燥，不会引起皮肤屏障功能减弱。相反，正常皮肤对治疗引起的外部刺激更具抵抗力。
