无论保湿剂的具体配方如何，其在治疗皮肤干燥症方面均有效：一项前瞻性、随机、双盲对照试验的结果
Moisturizers are effective in the treatment of xerosis irrespectively from their particular formulation: results from a prospective, randomized, double-blind controlled trial.
作者信息
Shim J H, Park J H, Lee J H, Lee D Y, Lee J H, Yang J M
机构信息
Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Department of Medical Device Management & Research, SAIHST, Sungkyunkwan University, Seoul, Korea.
出版信息
J Eur Acad Dermatol Venereol. 2016 Feb;30(2):276-81. doi: 10.1111/jdv.13472. Epub 2015 Nov 13.
BACKGROUND
Many companies claim that their moisturizers are superior to others based on their ingredients.
OBJECTIVE
To compare the efficacy and safety of the most popular moisturizers in the field.
METHODS
A randomized, double-blind, controlled study was performed on 80 patients with moderate to severe xerosis. The test agents included the newly developed cream containing topical recombinant human epidermal growth factor (EGF), its vehicle without EGF and four additional therapeutic moisturizers. The study subjects applied the test agents on designated skin areas twice daily for 4 weeks. All of the clinical assessments and non-invasive objective measurements were performed at baseline, and on days 14 and 28 of the study.
RESULTS
All of the test agents significantly improved the clinical symptoms of xerosis. The biophysical parameters similarly improved from baseline (P < 0.05). None of the test agents performed significantly better than did another.
CONCLUSION
In the treatment of xerosis, consistent and regular moisturizer use is much more important than the moisturizer's particular formulation.
背景
许多公司声称他们的保湿霜因其成分而优于其他产品。
目的
比较该领域最受欢迎的保湿霜的疗效和安全性。
方法
对80例中度至重度皮肤干燥患者进行了一项随机、双盲、对照研究。测试药物包括新开发的含局部重组人表皮生长因子（EGF）的乳膏、不含EGF的赋形剂以及另外四种治疗性保湿霜。研究对象每天在指定皮肤区域涂抹测试药物两次，持续4周。所有临床评估和非侵入性客观测量均在基线时以及研究的第14天和第28天进行。
结果
所有测试药物均显著改善了皮肤干燥的临床症状。生物物理参数同样较基线有所改善（P < 0.05）。没有一种测试药物的表现明显优于其他药物。
结论
在治疗皮肤干燥时，持续且规律地使用保湿霜比保湿霜的特定配方更为重要。
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