铜催化炔烃的亲电碳官能团化反应，得到高官能化的四取代烯烃。
Copper-catalyzed electrophilic carbofunctionalization of alkynes to highly functionalized tetrasubstituted alkenes.
机构信息
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.
出版信息
J Am Chem Soc. 2013 Apr 10;135(14):5332-5. doi: 10.1021/ja401840j. Epub 2013 Mar 29.
PMID:23521626
Abstract
Copper catalysts enable the electrophilic carbofunctionalization of alkynes with vinyl- and diaryliodonium triflates. The new process forms highly substituted alkenyl triflates from a range of alkynes via a pathway that is opposite to classical carbometalation. The alkenyl triflate products can be elaborated through cross-coupling reactions to generate synthetically useful tetrasubstituted alkenes.
摘要
铜催化剂能够实现炔烃与乙烯基和二芳基碘鎓三氟甲磺酸酯的亲电碳官能化。该新过程通过与经典碳金属化相反的途径，从一系列炔烃中形成高取代的烯基三氟甲磺酸酯。烯基三氟甲磺酸酯产物可以通过交叉偶联反应进行进一步修饰，生成具有合成用途的四取代烯烃。
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