通过碘鎓盐对二氟硼二吡咯亚甲基（BODIPYs）进行β位的直接C-H官能化反应。
Direct C-H functionalization of difluoroboron dipyrromethenes (BODIPYs) at β-position by iodonium salts.
作者信息
Ren Wenming, Xiang Huaijiang, Peng Chengyuan, Musha Zulipali, Chen Jingjing, Li Xin, Huang Ruimin, Hu Youhong
机构信息
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences 555 Zuchongzhi Road Shanghai 201203 China
College of Pharmaceutical Sciences, Zhejiang University 866 Yuhangtang Road Hangzhou 310058 China.
出版信息
RSC Adv. 2018 Feb 1;8(10):5542-5549. doi: 10.1039/c7ra13070h. eCollection 2018 Jan 29.
A copper-catalyzed direct C-H arylation or vinylation of BODIPYs at the β-position by iodonium salts has been developed, which provides facile access to a variety of mono-substituted BODIPY dyes. Interestingly, β-styryl BODIPY compound 9b exhibits apparent cytotoxicity after laser irradiation, which has great potential for photodynamic therapy.
已开发出一种铜催化的碘鎓盐使BODIPY在β位进行直接C-H芳基化或乙烯基化反应，该反应为合成多种单取代BODIPY染料提供了简便方法。有趣的是，β-苯乙烯基BODIPY化合物9b在激光照射后表现出明显的细胞毒性，在光动力疗法方面具有巨大潜力。
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