细胞死亡与存活中的禁止素配体：作用模式与治疗潜力
Prohibitin ligands in cell death and survival: mode of action and therapeutic potential.
作者信息
Thuaud Frédéric, Ribeiro Nigel, Nebigil Canan G, Désaubry Laurent
机构信息
Therapeutic Innovation Laboratory UMR 7200, CNRS/Université de Strasbourg, Faculté de Pharmacie, 67401 Illkirch Cedex, France.
出版信息
Chem Biol. 2013 Mar 21;20(3):316-31. doi: 10.1016/j.chembiol.2013.02.006.
Prohibitins (PHBs) are scaffold proteins that modulate many signaling pathways controlling cell survival, metabolism, and inflammation. Several drugs that target PHBs have been identified and evaluated for various clinical applications. Preclinical and clinical studies indicate that these PHB ligands may be useful in oncology, cardiology, and neurology, as well as against obesity. This review covers the physiological role of PHBs in health and diseases and current developments concerning PHB ligands.
抑制素（PHBs）是一种支架蛋白，可调节许多控制细胞存活、代谢和炎症的信号通路。已经鉴定并评估了几种靶向抑制素的药物用于各种临床应用。临床前和临床研究表明，这些抑制素配体可能在肿瘤学、心脏病学、神经病学以及对抗肥胖症方面有用。本综述涵盖了抑制素在健康和疾病中的生理作用以及关于抑制素配体的当前进展。
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