Brandeis University, Department of Biology & Volen Center for Complex Systems, 415 South Street-MS 008, Waltham, MA 02454-9110, USA.
Neuron. 2013 Mar 20;77(6):1002-16. doi: 10.1016/j.neuron.2013.03.007.
Theta and gamma frequency oscillations occur in the same brain regions and interact with each other, a process called cross-frequency coupling. Here, we review evidence for the following hypothesis: that the dual oscillations form a code for representing multiple items in an ordered way. This form of coding has been most clearly demonstrated in the hippocampus, where different spatial information is represented in different gamma subcycles of a theta cycle. Other experiments have tested the functional importance of oscillations and their coupling. These involve correlation of oscillatory properties with memory states, correlation with memory performance, and effects of disrupting oscillations on memory. Recent work suggests that this coding scheme coordinates communication between brain regions and is involved in sensory as well as memory processes.
θ 波和 γ 波频率在相同的脑区发生并相互作用，这一过程称为跨频耦合。在这里，我们回顾了以下假说的证据：双振荡形成了一种以有序方式表示多个项目的代码。这种编码形式在海马体中最为明显，其中不同的空间信息以 theta 周期的不同 γ 亚周期表示。其他实验已经测试了振荡及其耦合的功能重要性。这些实验包括振荡特性与记忆状态的相关性、与记忆表现的相关性以及对记忆的破坏对振荡的影响。最近的工作表明，这种编码方案协调了大脑区域之间的通信，并参与了感觉和记忆过程。
