硬腭鳞状细胞癌中颈转移对生存的影响。

Survival impact of cervical metastasis in squamous cell carcinoma of hard palate.

机构信息

Department of Head and Neck Surgery, Affiliated Tumor Hospital, Guangzhou Medical College, Guangzhou, Guangdong, China.

出版信息

Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Jul;116(1):23-7. doi: 10.1016/j.oooo.2013.01.005. Epub 2013 Mar 20.

DOI:10.1016/j.oooo.2013.01.005

PMID:23522641

Abstract

OBJECTIVE

Evaluate the impact of cervical metastasis on the survival of patients with squamous cell carcinoma (SCC) of the hard palate.

METHODS

155 cases of SCC of the hard palate hospitalized in Cancer Center, Sun Yat-sen University, from 1964 to 2008 were reviewed retrospectively.

RESULTS

The 5-year DSS rates for N+ and N0 patients were 21.54% and 47.36% (P = .048). The 5-year DSS rates were 47.36%, 27.48%, 15.55% and 0 for N0-N3 lesions, respectively (P = .041). Cervical metastasis was detected in 40% patients for initial consultation. After therapy, those individuals who presented with clinically negative necks had a 9.03% rate of cervical metastasis. Ultimately, 49.03% of patients manifested disease to the cervical lymph nodes.

CONCLUSION

The presence of cervical nodal disease in patients is associated with the decreased survival rates. SCC of the hard palate should be treated aggressively, and elective neck dissection should be considered because of the high rate of cervical metastasis.

摘要

目的

评估颈转移对硬腭鳞状细胞癌（SCC）患者生存的影响。

方法

回顾性分析 1964 年至 2008 年中山大学肿瘤防治中心收治的 155 例硬腭 SCC 患者。

结果

N+和 N0 患者的 5 年 DSS 率分别为 21.54%和 47.36%（P=0.048）。N0-N3 病变患者的 5 年 DSS 率分别为 47.36%、27.48%、15.55%和 0（P=0.041）。40%的患者初诊时发现颈部转移。治疗后，临床阴性颈部患者的颈部转移率为 9.03%。最终，49.03%的患者出现颈部淋巴结转移。