Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA; Michael E. DeBakey VA Medical Center, Houston, TX, USA; Psychiatry Research Center, Beijing Hui Long Guan Hospital, Peking University, Beijing, China.
Prog Neuropsychopharmacol Biol Psychiatry. 2013 Oct 1;46:197-9. doi: 10.1016/j.pnpbp.2013.03.003. Epub 2013 Mar 21.
Increasing evidence indicates that disturbances of antioxidant defense system and presence of oxidative stress can play a part in a wide range of neuropsychiatric disorders, including schizophrenia, bipolar disorder, and major depression, as well as antipsychotic-induced tardive dyskinesia (TD). Moreover, researchers have embarked on using antioxidant treatment as adjunct therapy for psychiatry disorders. Evidence from clinical, pre-clinical and epidemiological studies suggests that a benefit of using antioxidant compounds should be considered as an adjunctive therapy in these patients. These are some of the main perspectives that are reviewed by four articles in this special section. Overall, there has been growing recognition of the importance of oxidative stress in the pathophysiology of psychiatric disorders and the development of TD. The collection of articles in this special section will contribute to providing more efficacious treatments arising from a better appreciation of the roles of oxidative stress in these psychiatric disorders.
越来越多的证据表明，抗氧化防御系统的紊乱和氧化应激的存在可能在广泛的神经精神疾病中发挥作用，包括精神分裂症、双相情感障碍和重度抑郁症，以及抗精神病药引起的迟发性运动障碍（TD）。此外，研究人员已经开始将抗氧化治疗作为精神疾病的辅助治疗。来自临床、临床前和流行病学研究的证据表明，在这些患者中，应考虑使用抗氧化化合物作为辅助治疗的益处。这是这一特刊的四篇文章所综述的主要观点之一。总的来说，人们越来越认识到氧化应激在精神疾病的病理生理学和 TD 发展中的重要性。这个特刊中的文章将有助于提供更有效的治疗方法，这是由于更好地认识到氧化应激在这些精神疾病中的作用。
