Riaz Akhtar, Shreedhar Balasundari, Kamboj Mala, Natarajan S
Department of Oral Pathology and Microbiology, Career Post Graduate Institute of Dental Sciences and Hospital, C-1111, Indiranagar, Lucknow, 226016 India.
Springerplus. 2013 Dec;2(1):95. doi: 10.1186/2193-1801-2-95. Epub 2013 Mar 9.
Oral cancer is one of the most common neoplasm's and is ranked eighth in the cancer incidence worldwide. Early detection is of critical importance because survival rates markedly improve. In vivo staining is a simple, inexpensive, and fairly sensitive method. Involved 120 patients (50 with Premalignant Lesion, 50 with OSCC and 20 controls) stained by Methylene Blue (MB). The results of MB uptake were compared with a simultaneous biopsy of these lesions. Pathologically confirmed precancers and cancers were the positive targets of this screening, while hyperkeratosis without dysplasia and no evidence of malignancy were sorted as negative subjects of screening. The results revealed sensitivity of 91.4%, specificity of 66.6%, positive predictive value 97.7% and negative predictive value 33% leading to diagnostic accuracy of MB stain to 90%. We state that MB staining is useful diagnostic tool in community oral cancer screening programmes for high-risk individuals.
口腔癌是最常见的肿瘤之一，在全球癌症发病率中排名第八。早期检测至关重要，因为生存率会显著提高。体内染色是一种简单、廉价且相当敏感的方法。纳入120例患者（50例癌前病变患者、50例口腔鳞状细胞癌患者和20例对照），用亚甲蓝（MB）进行染色。将MB摄取结果与这些病变的同步活检结果进行比较。经病理证实的癌前病变和癌症是该筛查的阳性目标，而无发育异常的角化过度且无恶性证据的病变被归类为筛查的阴性对象。结果显示敏感性为91.4%，特异性为66.6%，阳性预测值为97.7%，阴性预测值为33%，MB染色的诊断准确性达到90%。我们指出，MB染色在社区口腔癌高危个体筛查项目中是一种有用的诊断工具。
