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以快速生长的甲状腺肿块为表现的原发性伯基特淋巴瘤

Primary Burkitt's Lymphoma Presenting as a Rapidly Growing Thyroid Mass.

作者信息

Yildiz Ibrahim, Sen Fatma, Toz Bahtiyar, Kilic Leyla, Agan Mehmet, Basaran Mert

机构信息

Department of Medical Oncology, Institute of Oncology, Istanbul University, Istanbul, Turkey.

出版信息

Case Rep Oncol. 2012 May;5(2):388-93. doi: 10.1159/000341260. Epub 2012 Jul 24.

Abstract

A 31-year-old male patient presented with a rapidly growing neck mass with normal thyroid function tests. Ultrasonography showed thyroidal expansion, a hypoechoic nodule that completely filled the right lobe, and 2 hypoechoic lymphadenopathies in the right jugulodigastric chain. The patient underwent right total and left subtotal thyroidectomy, following the diagnosis of nodular goiter; however, postoperative histopathological evaluation demonstrated primary Burkitt's lymphoma of the thyroid gland. The tumor was staged as stage 1, and R-hyper-CVAD protocol (rituximab, hyperfractionated cyclophosphamide, vincristine, doxorubicin and dexamethasone) was administered. The protocol was changed to R-CHOP after 4 cycles due to recurrent grade III/IV cytopenias and febrile neutropenia. The PET-CT scans performed after chemotherapy and at the 6-month follow-up were normal. In summary, we reported a case with a diagnosis of Burkitt's lymphoma, which is a rare type of primary thyroid lymphoma.

摘要

一名31岁男性患者,甲状腺功能检查正常,但出现颈部肿块迅速增大。超声检查显示甲状腺肿大,一个低回声结节完全占据右叶,右侧颈内静脉二腹肌链有2个低回声淋巴结肿大。在诊断为结节性甲状腺肿后,患者接受了右侧甲状腺全切除术和左侧甲状腺次全切除术;然而,术后组织病理学评估显示为原发性甲状腺伯基特淋巴瘤。肿瘤分期为1期,给予R-超CVAD方案(利妥昔单抗、超分割环磷酰胺、长春新碱、多柔比星和地塞米松)。由于复发的III/IV级血细胞减少和发热性中性粒细胞减少,4个周期后方案改为R-CHOP。化疗后及6个月随访时进行的PET-CT扫描均正常。总之,我们报告了一例诊断为伯基特淋巴瘤的病例,这是一种罕见的原发性甲状腺淋巴瘤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d00/3409505/e6b1c92342f6/cro-0005-0388-g01.jpg

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