Yildiz Ibrahim, Sen Fatma, Toz Bahtiyar, Kilic Leyla, Agan Mehmet, Basaran Mert
Department of Medical Oncology, Institute of Oncology, Istanbul University, Istanbul, Turkey.
Case Rep Oncol. 2012 May;5(2):388-93. doi: 10.1159/000341260. Epub 2012 Jul 24.
A 31-year-old male patient presented with a rapidly growing neck mass with normal thyroid function tests. Ultrasonography showed thyroidal expansion, a hypoechoic nodule that completely filled the right lobe, and 2 hypoechoic lymphadenopathies in the right jugulodigastric chain. The patient underwent right total and left subtotal thyroidectomy, following the diagnosis of nodular goiter; however, postoperative histopathological evaluation demonstrated primary Burkitt's lymphoma of the thyroid gland. The tumor was staged as stage 1, and R-hyper-CVAD protocol (rituximab, hyperfractionated cyclophosphamide, vincristine, doxorubicin and dexamethasone) was administered. The protocol was changed to R-CHOP after 4 cycles due to recurrent grade III/IV cytopenias and febrile neutropenia. The PET-CT scans performed after chemotherapy and at the 6-month follow-up were normal. In summary, we reported a case with a diagnosis of Burkitt's lymphoma, which is a rare type of primary thyroid lymphoma.
一名31岁男性患者,甲状腺功能检查正常,但出现颈部肿块迅速增大。超声检查显示甲状腺肿大,一个低回声结节完全占据右叶,右侧颈内静脉二腹肌链有2个低回声淋巴结肿大。在诊断为结节性甲状腺肿后,患者接受了右侧甲状腺全切除术和左侧甲状腺次全切除术;然而,术后组织病理学评估显示为原发性甲状腺伯基特淋巴瘤。肿瘤分期为1期,给予R-超CVAD方案(利妥昔单抗、超分割环磷酰胺、长春新碱、多柔比星和地塞米松)。由于复发的III/IV级血细胞减少和发热性中性粒细胞减少,4个周期后方案改为R-CHOP。化疗后及6个月随访时进行的PET-CT扫描均正常。总之,我们报告了一例诊断为伯基特淋巴瘤的病例,这是一种罕见的原发性甲状腺淋巴瘤。