Pasieka J L
Faculty of Medicine, University of Calgary; Division of General Surgery, University of Calgary, Calgary, Alberta, Canada.
Surg Oncol Clin N Am. 1998 Oct;7(4):707-20.
Not all thyroid carcinomas behave in an indolent fashion. There is a rare group of thyroid neoplasms that is biologically aggressive and carries a poor prognosis. These tumors include poorly differentiated tumors, anaplastic, and thyroid lymphomas. Poorly differentiated tumors are important tumors to recognize because aggressive surgical intervention appears to offer the best chance for long-term survival. Until recently, anaplastic carcinoma was universally fatal. Preoperative chemotherapy and hyperfractionated radiation has led to better local control and a few long-term survivors. The role of the surgeon in the treatment of the thyroid lymphomas remains controversial, however, most would agree that the surgeons role is limited, because these tumors are radiosensitive and chemosensitive.
并非所有甲状腺癌都呈惰性生长。有一类罕见的甲状腺肿瘤具有生物学侵袭性，预后较差。这些肿瘤包括低分化肿瘤、未分化癌和甲状腺淋巴瘤。低分化肿瘤是需要识别的重要肿瘤，因为积极的手术干预似乎为长期生存提供了最佳机会。直到最近，未分化癌仍是普遍致命的。术前化疗和超分割放疗已带来更好的局部控制效果，并出现了一些长期存活者。然而，外科医生在甲状腺淋巴瘤治疗中的作用仍存在争议，不过，大多数人会认同外科医生的作用有限，因为这些肿瘤对放疗和化疗敏感。
