Department of Pulmonary Medicine, Qilu Hospital, Shandong University, Ji'nan, Shandong, China.
Biosci Trends. 2013 Feb;7(1):42-9.
β-Catenin has been reported to play a crucial role in the invasion and metastasis of lung cancer. However, the value of β-catenin as a prognostic factor for non-small cell lung cancer (NSCLC) remains controversial. The present study systematically reviewed the evidence of predicting significance of β-catenin expression in NSCLC patients with meta-analysis. Twelve literatures were included by searching PubMed, Cochrane library, and EMBASE databases. Separate hazard ratio estimates and a 95% confidence interval (CI) for the prognostic value of β-catenin in NSCLC were extracted and merged from the included literatures. The summary hazard ratios were 1.91 (95% CI 1.60-2.28), indicating a worse overall survival for NSCLC patients with reduced β-catenin expression. There was no significant heterogeneity among the studies (X(2) = 12.41, p = 0.413, I(2) = 3.3%). Publication bias was not statistically significant. Sensitivity analysis showed that omission of any single study had little effect on the combined risk estimates. This meta-study revealed that decreased β-catenin expression denoted a poor prognosis in NSCLC patients.
β-连环蛋白已被报道在肺癌的侵袭和转移中发挥关键作用。然而，β-连环蛋白作为非小细胞肺癌（NSCLC）的预后因素的价值仍存在争议。本研究通过荟萃分析系统地回顾了β-连环蛋白表达对 NSCLC 患者预测意义的证据。通过搜索 PubMed、Cochrane 图书馆和 EMBASE 数据库，共纳入了 12 篇文献。从纳入的文献中提取并合并了β-连环蛋白在 NSCLC 中的预后价值的单独危险比估计值和 95%置信区间（CI）。汇总危险比为 1.91（95%CI 1.60-2.28），表明β-连环蛋白表达降低的 NSCLC 患者总体生存率较差。研究之间没有显著的异质性（X(2) = 12.41，p = 0.413，I(2) = 3.3%）。发表偏倚不具有统计学意义。敏感性分析表明，忽略任何一项研究对合并风险估计的影响很小。这项荟萃研究表明，β-连环蛋白表达降低表示 NSCLC 患者预后不良。
