Department of Surgery, St. Paul's Hospital, University of British Columbia, C303-1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6.
Department of Medical Genetics, University of British Columbia and Michael Smith Genome Sciences Center, British Columbia Cancer Research Center, Vancouver, BC, Canada.
Am J Surg. 2012 May;203(5):654-659. doi: 10.1016/j.amjsurg.2012.01.002. Epub 2012 Mar 7.
The objectives of this study were to determine the frequency and prognostic significance of beta-catenin expression in a cohort of non-small cell lung cancer (NSCLC) patients.
Tissue microarrays were constructed using clinically annotated formalin-fixed paraffin-embedded tumor samples from individuals diagnosed with NSCLC who underwent surgical resection with curative intent and had beta-catenin expression status determined by immunohistochemistry.
Negative beta-catenin expression was seen in 28% (103/370) of NSCLC cases and was prognostic of a reduced overall patient survival (P = .008) and also was significantly correlated with the presence of lymphatic invasion (P = .015). In multivariate analysis, the loss of beta-catenin expression retained independent prognostic significance and showed an adjusted hazard ratio of 3.18 (confidence interval, 1.46-6.91, P = .004) for reduced patient survival when adjusting for the presence of lymphatic invasion, tumor grade, nodal status, and tumor stage.
Beta-catenin represents an important prognostic marker in individuals diagnosed with surgically resectable NSCLC.
本研究的目的是确定在非小细胞肺癌（NSCLC）患者队列中β-连环蛋白表达的频率和预后意义。
使用组织微阵列，对经手术切除并具有治愈意图且通过免疫组织化学确定β-连环蛋白表达状态的个体的临床注释福尔马林固定石蜡包埋肿瘤样本进行构建。
28%（370 例中的 103 例）的 NSCLC 病例中观察到β-连环蛋白表达阴性，这与患者总生存时间降低相关（P=0.008），并且与淋巴浸润的存在显著相关（P=0.015）。在多变量分析中，β-连环蛋白表达缺失保留了独立的预后意义，并且在调整淋巴浸润、肿瘤分级、淋巴结状态和肿瘤分期的存在后，调整后的危险比为 3.18（置信区间，1.46-6.91，P=0.004）。
β-连环蛋白是诊断为可手术切除的 NSCLC 患者的重要预后标志物。
