Laboratory of Inflammation and Pain, Institute of Biological Sciences, UFMG, Belo Horizonte, Brazil.
Naunyn Schmiedebergs Arch Pharmacol. 2013 Jun;386(6):533-40. doi: 10.1007/s00210-013-0854-3. Epub 2013 Mar 26.
Several emerging lines of evidence support an anti-inflammatory role for nicotinic acid (niacin); however, its role in the regulation of leukocyte migration in response to inflammatory stimuli has not been elucidated until now. Herein, we have examined the effect of nicotinic acid on neutrophil recruitment in experimentally induced inflammation. We demonstrated that nicotinic acid treatment inhibited interleukin (IL)-8-induced, leukotriene (LT)B4-induced, and carrageenan-induced neutrophil migration into the pleural cavity of BALB/c mice and reduced neutrophil rolling and adherence in a mouse cremaster muscle preparation. Surprisingly, nicotinic acid treatment increased the level of the neutrophil chemoattractant KC in response to carrageenan. These results suggest that nicotinic acid plays an important role in the regulation of inflammation due to its ability to inhibit the actions of the neutrophil chemoattractants IL-8 and LTB4. Further inhibition of chemoattractants leads to impairment of leukocyte rolling and adherence to the vascular endothelium in the microcirculation of inflamed tissues.
有几项新出现的证据表明，烟酸（烟酰胺）具有抗炎作用；然而，直到现在，其在调节白细胞对炎症刺激的迁移中的作用仍未阐明。在此，我们研究了烟酸对实验性炎症中中性粒细胞募集的影响。我们发现，烟酸治疗抑制了白细胞介素（IL）-8 诱导、白三烯（LTB4）诱导和角叉菜胶诱导的中性粒细胞向 BALB/c 小鼠胸膜腔的迁移，并减少了鼠提睾肌制备中中性粒细胞的滚动和黏附。令人惊讶的是，烟酸治疗增加了中性粒细胞趋化因子 KC 对角叉菜胶的反应水平。这些结果表明，烟酸通过抑制中性粒细胞趋化因子 IL-8 和 LTB4 的作用，在炎症调节中发挥重要作用。进一步抑制趋化因子会导致白细胞在炎症组织的微循环中滚动和黏附到血管内皮的功能受损。
