Yang Yaling, Brazier John, Tsuchiya Aki
Brunel University, Health Economics Research Group, Uxbridge, UK (YY).
School of Health and Related Research, University of Sheffield, Sheffield, UK (JB, AT)
Med Decis Making. 2014 Jan;34(1):42-53. doi: 10.1177/0272989X13480428. Epub 2013 Mar 22.
The generic preference-based measures (GPBMs) of health have been widely used to obtain health utility scores for calculating quality-adjusted life-years (QALYs) for economic evaluations. It has been recognized that GPBMs may miss relevant or important dimensions of health for some specific medical conditions. The objective of this study is to explore the effect of extending the current EQ-5D descriptive system by adding a sleep dimension.
A new instrument, EQ-5D+Sleep, is proposed by adding a sleep dimension to the EQ-5D. Based on an orthogonal design, 18 EQ-5D+Sleep states and EQ-5D states were selected and a valuation study was undertaken whereby 160 members of the generic public in South Yorkshire, UK, were interviewed using time tradeoff (TTO). Econometric models have been fitted to the data. Two null hypotheses were tested: 1) the coefficient for the sleep dimension is not significant; and 2) the inclusion of the sleep dimension has no impact on the way people value the original dimensions of EQ-5D.
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The results support these two null hypotheses. There seems to be no benefit to adding a sleep dimension to the EQ-5D. Research is required to explore the method of adding dimensions to existing descriptive systems of health.
基于通用偏好的健康测量方法（GPBMs）已被广泛用于获取健康效用分数，以计算经济评估中的质量调整生命年（QALYs）。人们已经认识到，对于某些特定医疗状况，GPBMs可能会遗漏健康的相关或重要维度。本研究的目的是探讨通过增加睡眠维度来扩展当前EQ - 5D描述系统的效果。
通过在EQ - 5D基础上增加睡眠维度，提出了一种新的工具EQ - 5D + 睡眠。基于正交设计，选择了18种EQ - 5D + 睡眠状态和EQ - 5D状态，并进行了一项估值研究，通过时间权衡法（TTO）对英国南约克郡的160名普通公众进行了访谈。已对数据拟合了计量经济学模型。检验了两个零假设：1）睡眠维度的系数不显著；2）纳入睡眠维度对人们评估EQ - 5D原始维度的方式没有影响。
结果支持这两个零假设。在EQ - 5D中增加睡眠维度似乎没有益处。需要开展研究以探索向现有健康描述系统中添加维度的方法。
