Kangwanrattanakul Krittaphas, Phimarn Wiraphol
a Faculty of Pharmaceutical Sciences , Burapha University , Chonburi , Thailand.
b Faculty of Pharmacy , Mahasarakham University , Mahasarakham , Thailand.
Expert Rev Pharmacoecon Outcomes Res. 2019 Aug;19(4):431-443. doi: 10.1080/14737167.2019.1637736. Epub 2019 Jul 15.
: As the five dimensions of the EQ-5D might be insensitive to some populations or conditions, adding one or more specific 'bolt-on dimensions', to the EQ-5D may improve its validity and relevance for those groups. Various bolt-on dimensions have been identified and tested the effect on the psychometric performance and utility measurement. Therefore, this systematic review was to review all bolt-on dimensions and report the results of those two effects. : Twelve studies were identified through PubMed, Scopus, and Web of Sciences from inception to January 2019. The bolt-on dimensions generally improved the EQ-5D's psychometric performance when compared with the standard version. However, evidence is lacking about the impact of bolt-on dimensions on responsiveness, reliability and known-groups validity. Evidence was also mixed for adding a sleep dimension, while interpersonal relationships did not promote a significant improvement on utility measurement. : Adding bolt-on dimensions could enhance the discriminative power and utility measurement of the EQ-5D; however, careful investigation of the sleep and interpersonal relationships is required since the evidence did not support a significant improvement. Further investigation of the identified bolt-on dimensions on all of the psychometric performance and the incremental utility scores derived from TTO is greatly encouraged.
由于EQ-5D的五个维度可能对某些人群或情况不敏感，在EQ-5D中添加一个或多个特定的“附加维度”可能会提高其对这些群体的有效性和相关性。已经确定了各种附加维度，并测试了其对心理测量性能和效用测量的影响。因此，本系统评价旨在回顾所有附加维度，并报告这两种影响的结果。：通过PubMed、Scopus和Web of Sciences从创刊至2019年1月共检索到12项研究。与标准版本相比，附加维度通常会改善EQ-5D的心理测量性能。然而，关于附加维度对反应性、可靠性和已知群体有效性的影响缺乏证据。添加睡眠维度的证据也不一致，而人际关系对效用测量没有显著改善。：添加附加维度可以增强EQ-5D的区分能力和效用测量；然而，由于证据不支持显著改善，因此需要对睡眠和人际关系进行仔细研究。强烈鼓励进一步研究已确定的附加维度对所有心理测量性能以及从TTO得出的增量效用得分的影响。
