金纳米棒介导的多柔比星控制释放：用于高效药物输送的纳米针。
Gold nanorods mediated controlled release of doxorubicin: nano-needles for efficient drug delivery.
机构信息
N. S. N. Research Centre for Nanotechnology and Bionanotechnology, Jambhul Phata, Ambernath (W), 421 505, Maharashtra, India.
出版信息
J Mater Sci Mater Med. 2013 Jul;24(7):1671-81. doi: 10.1007/s10856-013-4915-4. Epub 2013 Mar 23.
Use of cysteamine hydrochloride (Cys-HCl) protected gold nanorods (GNRs) as efficient carrier of widely used anti-cancer drug doxorubicin using folic acid as navigational molecule is presented in this work. GNRs were found to have excellent drug loading capacity of >97 %. A detailed comprehension of in vitro drug release profile under ideal physiological condition was found to obey 1st order kinetics at pH 6.8, 5.3 and 7.2, an ideal milieu for drug delivery to solid tumours.
本工作提出了使用半胱胺盐酸盐（Cys-HCl）保护的金纳米棒（GNR）作为广泛使用的抗癌药物阿霉素的有效载体，并用叶酸作为导航分子。研究发现，GNR 具有出色的药物负载能力，超过 97%。在理想的生理条件下，详细了解体外药物释放曲线，发现遵循 pH 值为 6.8、5.3 和 7.2 时的 1 级动力学，这是向实体瘤输送药物的理想环境。
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