LaVan David A, McGuire Terry, Langer Robert
Department of Mechanical Engineering, Yale University, New Haven, Connecticut 06520-8284, USA.
Nat Biotechnol. 2003 Oct;21(10):1184-91. doi: 10.1038/nbt876.
Recent developments in the application of micro- and nanosystems for drug administration include a diverse range of new materials and methods. New approaches include the on-demand activation of molecular interactions, novel diffusion-controlled delivery devices, nanostructured 'smart' surfaces and materials, and prospects for coupling drug delivery to sensors and implants. Micro- and nanotechnologies are enabling the design of novel methods such as radio-frequency addressing of individual molecules or the suppression of immune response to a release device. Current challenges include the need to balance the small scale of the devices with the quantities of drugs that are clinically necessary, the requirement for more stable sensor platforms, and the development of methods to evaluate these new materials and devices for safety and efficacy.
微纳系统在药物给药应用方面的最新进展包括各种各样的新材料和方法。新方法包括分子相互作用的按需激活、新型扩散控制给药装置、纳米结构的“智能”表面和材料，以及将药物递送与传感器和植入物相结合的前景。微纳技术正在推动新型方法的设计，如对单个分子进行射频寻址或抑制对释放装置的免疫反应。当前的挑战包括需要在装置的小尺寸与临床所需药物量之间取得平衡、对更稳定的传感器平台的需求，以及开发评估这些新材料和装置安全性和有效性的方法。
