Kirby Institute, The University of New South Wales, Sydney NSW 2052, Australia.
J Infect. 2013 Jun;66(6):503-11. doi: 10.1016/j.jinf.2013.03.005. Epub 2013 Mar 23.
Human papillomavirus (HPV) types 6 and 11 are most commonly associated with ano-genital warts. There are few data on the sero-epidemiology of HPV6 and HPV11 among homosexual men.
Behavioural data and sera for antibodies to HPV6 and HPV11 capsid protein L1 were collected annually for 1427 HIV negative and 245 HIV positive homosexual men. For HIV negative men, a combined variable, HPV6/11, was created (HPV 6 and/or 11) to analyse predictors of seroprevalence and seroincidence.
High rates of HPV6 and HPV11 seroprevalence were found (39.2-53.2% of men). For HPV6/11 (HIV negative men only), seroprevalence was associated with higher numbers of sexual partners, longer history of sexual activity and seropositivity for several sexually transmissible infections. Each year, 12.6% of men younger than 25 years seroconverted. Seroincidence (5.9/100PY) was associated with younger age, more recent male sexual partners, receptive anal fingering and anal chlamydia. Seropositivity and seroconversion were strongly associated with past and incident anal warts.
HPV6 and HPV11 seropositivity were common among homosexual men. Among HIV negative men, HPV6/11 seroprevalence and seroincidence correlated closely with markers of sexual activity. The high numbers of young men seroconverting each year suggests a role for prophylactic vaccination of young gay men.
Ano-genital warts, caused by human papillomavirus, are very common. In a community cohort of Australian homosexual men, HPV6 and 11 seroprevalence and seroincidence were high and were associated with past and incident anal warts and other markers of sexual activity.
人乳头瘤病毒（HPV）6 型和 11 型与肛门生殖器疣的关系最为密切。同性恋男性 HPV6 和 HPV11 的血清流行病学数据较少。
每年对 1427 名 HIV 阴性和 245 名 HIV 阳性同性恋男性进行性行为数据和 HPV6 和 HPV11 衣壳蛋白 L1 抗体血清学检测。对于 HIV 阴性男性，创建了一个组合变量 HPV6/11（HPV6 和/或 11），以分析血清流行率和血清发生率的预测因素。
发现 HPV6 和 HPV11 的血清流行率较高（39.2-53.2%的男性）。对于 HPV6/11（仅 HIV 阴性男性），血清流行率与性伴侣数量较多、性活动史较长以及几种性传播感染的血清阳性有关。每年，有 12.6%的 25 岁以下男性发生血清转换。血清发生率（5.9/100PY）与年龄较小、最近的男性性伴侣、接受肛门指诊和肛门衣原体感染有关。血清阳性和血清转换与过去和现在的肛门疣密切相关。
HPV6 和 HPV11 的血清阳性在同性恋男性中很常见。在 HIV 阴性男性中，HPV6/11 的血清流行率和血清发生率与性行为标志物密切相关。每年有大量的年轻男性发生血清转换，这表明对年轻的同性恋男性进行预防性疫苗接种可能具有重要意义。
肛门生殖器疣是由人乳头瘤病毒引起的，非常常见。在澳大利亚同性恋男性的社区队列中，HPV6 和 11 的血清流行率和血清发生率较高，与过去和现在的肛门疣以及其他性行为标志物有关。
