Zakharov A V, Khinivtseva E V, Poverennova I E, Gindullina E A, Vlasov Ia V, Sineok E V
Zh Nevrol Psikhiatr Im S S Korsakova. 2013;113(2 Pt 2):28-31.
We followed up 102 patients with a monofocal clinically isolated syndrome (CIS) during 8 years. Factors determining its transition to definite multiple sclerosis were singled out according to the data of anamnesis and MRI scans. Age of patients at the onset of CIS and the volume of demyelination measured by the first MRI were the most significant predictors of the transition of CIS to definite multiple sclerosis. A mathematical model based on logistic regression analysis for the estimation of the risk of this transition is suggested.
我们对102例单病灶临床孤立综合征（CIS）患者进行了8年的随访。根据病史和磁共振成像（MRI）扫描数据，找出了决定其转变为明确多发性硬化症的因素。CIS发病时患者的年龄以及首次MRI测量的脱髓鞘体积是CIS转变为明确多发性硬化症的最显著预测因素。本文提出了一种基于逻辑回归分析的数学模型，用于评估这种转变的风险。
