Mogoşanu G D, Popescu Florina Carmen, Busuioc Cristina Jana, Lascăr I, Mogoantă L
Department of Pharmacognosy & Phytotherapy, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, Romania.
Rom J Morphol Embryol. 2013;54(1):107-13.
During the healing process of third-degree skin burns, a very complex response involves different cells and tissues linked together by intra- and extra-cellular mechanisms. For the restoration of damaged tissues, angiogenesis is the key point in the formation of new blood vessels. By their emollient, astringent, antiseptic, anti-inflammatory, biostimulator, epithelizing and cicatrizing effect, active principles from natural products contribute to the acceleration of the wound-healing process. In our study, we investigated the angiogenesis process in experimental model of third-degree skin burns treated with three topical preparations (cold-creams) containing 10% herbal extracts, comparing with 1% sulfadiazine cream and cold-cream base respectively. By their biostimulator, epithelizing and cicatrizing effect, cold-creams with herbal extracts are locally modulators of the cellular response and support the wound healing. The phytocomplex stimulates the favorable evolution of the burnt skin wounds and the development of neoangiogenesis capillaries.
在三度皮肤烧伤的愈合过程中，一种非常复杂的反应涉及通过细胞内和细胞外机制连接在一起的不同细胞和组织。对于受损组织的修复，血管生成是新血管形成的关键点。天然产物中的活性成分通过其润肤、收敛、防腐、抗炎、生物刺激、上皮化和瘢痕形成作用，有助于加速伤口愈合过程。在我们的研究中，我们研究了用三种含有10%草药提取物的外用制剂（冷霜）治疗的三度皮肤烧伤实验模型中的血管生成过程，并分别与1%磺胺嘧啶霜和冷霜基质进行比较。含有草药提取物的冷霜通过其生物刺激、上皮化和瘢痕形成作用，是细胞反应的局部调节剂，并支持伤口愈合。植物复合物刺激烧伤皮肤伤口的良好演变和新血管生成毛细血管的发育。
