Mogoşanu G D, Popescu Florina Carmen, Busuioc Cristina Jana, Pârvănescu H, Lascăr I
Department of Pharmacognosy and Phytotherapy, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Rom J Morphol Embryol. 2012;53(2):249-62.
Local cellular response plays a major role in restoring skin integrity, in burns with infectious complications, chronic fibrous sequelae, etc. For the study of wound-healing process, different experimental models of skin burn were developed. Mice, rats, rabbits and guinea pigs are the most used laboratory animals, kept under standard conditions of light, temperature, food and water (ad libitum). Commonly, by intramuscular injection, general anesthesia was induced with ketamine hydrochloride. Most times, skin burns were inflicted on the dorsal region of animals. Metal devices with different shapes and weights, heated in water at various temperatures were applied locally, for few seconds. The paper reports on 65 natural medicinal products recommended for the external and internal treatment of skin damages (first- or second-degree burns, various wounds, ulcerations). Some of them are traditionally used in the Romanian ethnopharmacology, supporting the wound-healing process mainly because of their epithelizing, astringent, emollient, demulcent, anti-inflammatory, antimicrobial, immunomodulatory and antioxidant properties.
局部细胞反应在恢复皮肤完整性方面起着重要作用，在伴有感染并发症、慢性纤维后遗症等的烧伤中也是如此。为了研究伤口愈合过程，人们开发了不同的皮肤烧伤实验模型。小鼠、大鼠、兔子和豚鼠是最常用的实验动物，饲养在光照、温度、食物和水（随意摄取）的标准条件下。通常，通过肌肉注射，用盐酸氯胺酮诱导全身麻醉。大多数情况下，在动物的背部造成皮肤烧伤。将不同形状和重量的金属装置在不同温度的水中加热后局部应用几秒钟。本文报道了65种推荐用于皮肤损伤（一度或二度烧伤、各种伤口、溃疡）内外治疗的天然药物产品。其中一些在罗马尼亚民族药理学中传统上被使用，主要因其具有上皮化、收敛、润肤、缓和、抗炎、抗菌、免疫调节和抗氧化特性而支持伤口愈合过程。
