Enciu Manuela, Aşchie Mariana, Deacu Mariana, Poinăreanu I
Department of Pathology, Faculty of Medicine, "Ovidius" University, Constanta, Romania.
Rom J Morphol Embryol. 2013;54(1):191-4.
Mucoid adenocarcinoma of the prostate is a very rare variant, account less than 1% of prostatic adenocarcinomas. In this respect, the most common histopathological type of prostate cancer is acinar adenocarcinoma. Diagnosis of this variant is very important due to peculiarities: aggressive biologic behavior, poor response to radiotherapy. Although these tumors are not as hormonally responsive as acinar adenocarcinomas, some of them respond to androgen withdrawal. Before making a diagnosis of primary mucinous adenocarcinoma, is necessary to exclude an extraprostatic malignant neoplasia, especially from the bladder or bowel. We present the case of a male patient who suffered a transurethral prostatic resection surgery. Histopathological examination revealed malignant tumor cells floating in a pool of mucus or even acini mixed with signet ring cells. A particular aspect is that floating mucus cells have a non-papillary pattern similar to colloid carcinoma of the breast. The use of monoclonal antibody revealed positive immunoreaction of malignant cells for prostatic specific markers and excluded neoplastic invasion of the bladder or bowel carcinoma.
前列腺黏液腺癌是一种非常罕见的变异型，占前列腺腺癌的比例不到1%。在这方面，前列腺癌最常见的组织病理学类型是腺泡腺癌。由于其具有侵袭性生物学行为、对放疗反应不佳等特点，诊断这种变异型非常重要。虽然这些肿瘤不像腺泡腺癌那样对激素有反应，但其中一些对雄激素剥夺有反应。在诊断原发性黏液腺癌之前，有必要排除前列腺外恶性肿瘤，尤其是来自膀胱或肠道的。我们报告一例接受经尿道前列腺切除术的男性患者。组织病理学检查显示恶性肿瘤细胞漂浮在黏液池中，甚至有腺泡与印戒细胞混合。一个特别的方面是，漂浮的黏液细胞具有类似于乳腺黏液癌的非乳头状模式。使用单克隆抗体显示恶性细胞对前列腺特异性标志物呈阳性免疫反应，并排除了膀胱或肠道癌的肿瘤侵犯。
