Sergeyev E, Wagner I, Neef M, Adler M, Körner A, Kiess W
Department für Frauen- und Kindermedizin, Klinik für Kinder und Jugendliche, Universitätsklinikum Leipzig, Liebigstr. 20a, 04103, Leipzig, Deutschland.
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2013 Apr;56(4):511-6. doi: 10.1007/s00103-012-1636-7.
As obesity has become more prevalent, the incidence of type 2 diabetes mellitus in children and adolescents has also increased. Obesity during adolescence leads to an increased risk for disease and premature death during adulthood, independent of obesity during adulthood. Obesity is the major risk factor impacting insulin sensitivity. Subjects with insulin resistance are at risk for progression to diabetes. Type 2 diabetes mellitus in obese children and adolescents is frequently asymptomatic. It is essential to identify children at high risk who need aggressive lifestyle modification focused on weight reduction and increased physical activity. Early detection and therapy of obese children and adolescents with type 2 diabetes may reduce the risk of cardiometabolic consequences and other long-term complications in adulthood.
随着肥胖现象日益普遍，儿童和青少年2型糖尿病的发病率也有所上升。青春期肥胖会增加成年后患疾病和过早死亡的风险，且与成年期肥胖无关。肥胖是影响胰岛素敏感性的主要危险因素。胰岛素抵抗的个体有发展为糖尿病的风险。肥胖儿童和青少年的2型糖尿病通常没有症状。识别出需要积极改变生活方式以减轻体重和增加身体活动的高危儿童至关重要。对肥胖的儿童和青少年2型糖尿病患者进行早期检测和治疗，可能会降低成年后发生心脏代谢后果和其他长期并发症的风险。
