Lau K, Höger P H
Abteilung Pädiatrische Dermatologie, Katholisches Kinderkrankenhaus Wilhelmstift, Liliencronstr. 130, 22149, Hamburg, Deutschland.
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2013 Apr;56(4):539-42. doi: 10.1007/s00103-012-1641-x.
While the impact of obesity on diabetes, cardiovascular disease and carcinoma development has been studied extensively, only little attention has been paid to its influence on the skin. Obesity alters the skin barrier, can induce skin manifestations, and worsens existing skin diseases like psoriasis. Cutaneous manifestations of obesity may be pseudoacanthosis nigricans, fibroma pendulans (skin tags, fibroepithelial polyps) and striae distensae. Obesity is also associated with hyperandrogenism in women and girls, promoting acne vulgaris, hirsutism, and androgenetic alopecia. In addition, there is a pathogenic association between obesity and psoriasis: the release of pro-inflammatory factors from fat tissue results in the worsening of psoriasis; an association between the severity of psoriasis and the body mass index has been shown. Obesity promotes skin infections like erysipelas and intertrigo.
虽然肥胖对糖尿病、心血管疾病和癌症发展的影响已得到广泛研究，但人们对其对皮肤的影响关注甚少。肥胖会改变皮肤屏障，可诱发皮肤表现，并使如银屑病等现有皮肤病恶化。肥胖的皮肤表现可能为假性黑棘皮病、皮垂纤维瘤（皮肤软纤维瘤、纤维上皮性息肉）和膨胀纹。肥胖还与女性和女孩的高雄激素血症有关，会加重寻常痤疮、多毛症和雄激素性脱发。此外，肥胖与银屑病之间存在致病关联：脂肪组织释放的促炎因子会导致银屑病恶化；银屑病的严重程度与体重指数之间已显示存在关联。肥胖会促进丹毒和擦烂等皮肤感染。
